[The analysis of prescription frequency and the factors on adverse reactions of NSAIDs for post-operative pain in orthopedic patients]
| Autor: | Yuya Ise, Kozo Takayama, Shirou Katayama, Yosuke Murota, Minoru Narita, Masaaki Hirano, Tsutomu Suzuki, Shizuka Soh |
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| Rok vydání: | 2003 |
| Předmět: |
musculoskeletal diseases
Adult Male medicine.medical_specialty Peptic Ulcer Pharmacist Pharmaceutical Science Logistic regression Pharmacists digestive system Drug Prescriptions Japan Cost Savings Intervention (counseling) medicine Humans Orthopedic Procedures Medical prescription skin and connective tissue diseases Intensive care medicine Adverse effect Aged Pharmacology Pain Postoperative Phenylpropionates business.industry Anti-Inflammatory Agents Non-Steroidal Loxoprofen Health Care Costs Middle Aged digestive system diseases Pharmaceutical care Logistic Models Orthopedic surgery Physical therapy Female business medicine.drug |
| Zdroj: | Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 123(7) |
| ISSN: | 0031-6903 |
| Popis: | Recently, adverse reaction of non-steroidal anti-inflammatory drugs (NSAIDs) is the critical problem, although NSAIDs are one of the most commonly used classes of medications worldwide. Therefore, it is worthwhile to investigate the prescription frequency and the factors on adverse reactions of NSAIDs for post-operative pain in orthopedic patients of our hospital. In orthopedic field, loxoprofen was most prescribed in various kinds of NSAIDs. Logistic regression analysis strongly indicated that previous adverse reaction or allergy caused by drugs (not NSAIDs) or food is the important role in the adverse reaction of NSAIDs. In addition, significant correlation was observed between previous illness of gastrointestinal ulcer and gastrointestinal complication of NSAIDs. Moreover, the present study point out that pharmacist clinical intervention against the adverse reaction of NSAIDs may be saved on medical costs. Although further investigation may be needed, these present studies provide the good information for our medication management and instruction tasks (i.e. pharmaceutical care and counseling for inpatients) for post-operative pain of orthopedic patients. |
| Databáze: | OpenAIRE |
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