Bergamot essential oil nanoemulsions: antimicrobial and cytotoxic activity

Autor: Maria Luisa Balestrieri, Domenico Castaldo, Giovanna Ferrari, Francesco Donsì, Enrico Marchese, Nunzia D'Onofrio
Přispěvatelé: Marchese, E., D'Onofrio, N., Balestrieri, M. L., Castaldo, D., Ferrari, G., Donsì, F.
Rok vydání: 2020
Předmět:
Preservative
Cell Survival
Acyclic Monoterpenes
Drug Compounding
Bergamot essential oil
nanoemulsion
Cyclohexane Monoterpenes
Microbial Sensitivity Tests
Saccharomyces cerevisiae
Linalyl acetate
General Biochemistry
Genetics and Molecular Biology
03 medical and health sciences
chemistry.chemical_compound
0404 agricultural biotechnology
Anti-Infective Agents
Linalool
Lactobacillus
Escherichia coli
Oils
Volatile
Humans
Plant Oils
Food science
Bicyclic Monoterpenes
Cell Proliferation
030304 developmental biology
Lactobacillus delbrueckii
0303 health sciences
antimicrobial activity
Aqueous solution
Caco2 cells
biology
Food preservation
04 agricultural and veterinary sciences
bergamot essential oil
stability
Antimicrobial
biology.organism_classification
Antineoplastic Agents
Phytogenic
040401 food science
cytotoxicity
chemistry
Monoterpenes
Emulsions
Caco-2 Cells
Limonene
Zdroj: Zeitschrift für Naturforschung C. 75:279-290
ISSN: 1865-7125
0939-5075
DOI: 10.1515/znc-2019-0229
Popis: Bergamot essential oil (BEO) is well-known for its food preservation activity, as well as anticancer efficacy. However, the poor BEO water solubility and deriving low bioaccessibility have limited its wider applications. The incorporation in nanoemulsions of BEO and its refined fractions was investigated to enhance its dispersibility in water to promote its antimicrobial activity, tested against Escherichia coli, Lactobacillus delbrueckii, and Saccharomyces cerevisiae, and its cytotoxicity already at low concentrations. Different nanoemulsion formulations were tested based on food-grade ingredients, which were characterized in terms of hydrodynamic diameter and polydispersity index, and physical stability. The antimicrobial activity against all the tested micro-organisms was observed to be higher for BEO in its initial composition, than the light fraction, richer in d-limonene, ß-pinene, and γ-terpinene, or the heavy fraction, richer in linalyl acetate and linalool. Remarkably, the use of BEO nanoemulsions notably enhanced the antimicrobial activity for all the tested oils. BEO exhibited also a measurable cytotoxic activity against Caco-2 cells, which was also enhanced by the use of the different nanoemulsions tested, in comparison with free oil, which discourages the direct use of BEO nanoemulsions as a food preservative. Conversely, BEO nanoemulsions might find use in therapeutic applications as anticarcinogenic agents.
Databáze: OpenAIRE
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