The Effects of Syphilis Infection on CD4 Counts and HIV-1 RNA Viral Loads in Blood: A Cohort Study Among MSM with HIV Infection in Sanglah Hospital Bali-Indonesia
| Autor: | I Ketut Agus Somia, Igaa Elis Indira, AA Sagung Sawitri, Komang Agus Trisna Amijaya, Ketut Tuti Parwati Merati, Nittaya Phanuphak, Dewi Dian Sukmawati, Made Yogi Oktavian Prasetia |
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| Rok vydání: | 2016 |
| Předmět: |
msm
hiv syphilis medicine.medical_specialty 030231 tropical medicine Human immunodeficiency virus (HIV) lcsh:Medicine Syphilis infection medicine.disease_cause Hiv 1 rna Men who have sex with men 03 medical and health sciences 0302 clinical medicine Internal medicine medicine 030212 general & internal medicine lcsh:R5-920 business.industry lcsh:R virus diseases General Medicine medicine.disease Immunology Cohort hiv-1 rna cd4 count Syphilis lcsh:Medicine (General) business Viral load Cohort study |
| Zdroj: | Bali Medical Journal, Vol 5, Iss 3, Pp 391-394 (2016) |
| ISSN: | 2302-2914 2089-1180 |
| DOI: | 10.15562/bmj.v5i3.283 |
| Popis: | Background: Men who have sex with men (MSM), particularly those with HIV infection, are at high risk for contracting syphilis. However, little is known about the effect of syphilis on HIV-1 RNA and CD4 count among HIV infected MSM. Methods: MSM were enrolled into the MSM-VCT study cohort at Sanglah Hospital in Bali between June 22nd 2011 to February 13rd 2012. All participants had anti-HIV test and VDRL test at baseline, with TPHA confirmation for reactive VDRL results. Plasma HIV-1 RNA levels and CD4 counts were measured at baseline and month 6 visits. T-test or non-parametric Mann-Whitney test were used to compare changes in CD4 counts and HIV-1 RNA levels between those with and without syphilis. To analyze difference of baseline and 6 month visit in each group, we used paired students t-test. Results: HIV positive MSM with syphilis co-infection had significantly higher mean baseline CD4 count than those without syphilis (P=0.017). No difference was seen for median baseline plasma HIV-1 RNA between HIV positive MSM with and without syphilis (P=0.885). Mean change in CD4 count from baseline to month 6 was similar between HIV positive MSM with syphilis (n=11) and without syphilis (n=20) (P=0.860). Similarly, no significant difference in median HIV-1 RNA change was identified between those with (n=8) and without syphilis (n=11) (P=1.000). Conclusions: HIV positive MSM with syphilis co-infection had higher CD4 cell counts. However, syphilis influences the changes of CD4 cell count and HIV-1 RNA 6 months after HIV diagnosis, but not statistically significance. |
| Databáze: | OpenAIRE |
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