Congenital Adrenal Hyperplasia as a Cause of Secondary Hypertension in Adults: Three Cases

Autor:	Ekrem Algün, İnan Anaforoğlu, Kerem Ersoy
Přispěvatelé:	Belirlenecek
Rok vydání:	2019
Předmět:	Pediatrics medicine.medical_specialty hypertension business.industry Endocrinology Diabetes and Metabolism Congenital adrenal hyperplasia Secondary hypertension medicine.disease secondary hypertension hypokalemia Internal Medicine medicine business
Zdroj:	The Turkish Journal of Endocrinology and Metabolism. 23:135-140
ISSN:	1308-9846 1301-2193
DOI:	10.25179/tjem.2019-65085
Popis:	WOS: 000473267000011 Congenital adrenal hyperplasia is a group of hereditary disorders originating from enzymatic defects in steroidogenesis, resulting in impaired cortisol synthesis in the adrenal cortex. The rare forms of congenital adrenal hyperplasia characterized by hypertension and hypokalemia include 11-beta and 17-alpha hydroxylase deficiencies. We described three cases of congenital adrenal hyperplasia, two with 11-alpha hydroxylase and one with 17-alpha hydroxylase deficiency, each presenting with hypertension and hypokalemia in adulthood. In addition, 11-beta hydroxylase deficiency cases showed precocious puberty with testicular adrenal rest tumor and adrenal myelolipoma, whereas the patient with 17-alpha hydroxylase deficiency showed sexual infantilism. Congenital adrenal hyperplasia is a rare cause of secondary hypertension in adults. It is particularly considered in patients with sexual maturation disorders, such as precocious puberty, delayed puberty, or sexual infantilism, and in those with hypertension and hypokalemia.
Databáze:	OpenAIRE
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