The effects of chlordiazepoxide HCl administration upon punishment and conditioned suppression in the rat
| Autor: | Paul Garrud, Peter Salmon, J. N. P. Rawlins, J. Feldon, Jeffrey A. Gray |
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| Rok vydání: | 1980 |
| Předmět: |
Male
Pharmacology Electroshock medicine.medical_specialty Punishment (psychology) Chemistry Chlordiazepoxide Response suppression Rats Endocrinology Punishment Internal medicine Shock (circulatory) medicine Animals Conditioning Operant Random interval Rate dependency Chlordiazepoxide hcl Conditioned Suppression medicine.symptom medicine.drug |
| Zdroj: | Psychopharmacology. 70:317-322 |
| ISSN: | 1432-2072 0033-3158 |
| DOI: | 10.1007/bf00427894 |
| Popis: | Rats were trained to lever press for sucrose on a random interval (RI) 64-s schedule. During a 55 min session there were four 3 min "intrusion periods" signalled by a flashing house-light. In experiment 1 there were two groups matched for baseline response rate. During the intrusion periods one group received response-independent footshock on an independent RI 64 schedule; the other group received response-contingent shock on this schedule. Shock intensity was varied for each rat to match degree of response suppression between the two groups. Chlordiazepoxide HCl (CDP) in doses 0.5-5 mg/kg alleviated response suppression equally in both groups. Experiment II followed the same procedure, except that all animals had the same shock intensity, producing greater response suppression in the response-contingent shock groups. CDP alleviated response suppression more in the response-contingent shock groups, significantly so at 5 mg/kg, nonsignificantly at 1 mg/kg. These results suggest that previous reports that CDP differentially alleviates the response suppression produced by response-contingent shock are an artefact of rate dependency. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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