The Transcriptional Control of Trunk Neural Crest Induction, Survival, and Delamination
| Autor: | Elizabeth M. A. Hirst, James Briscoe, Martin Cheung, Anita Mynett, Andreas Schedl, Marie-Christine Chaboissier |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
animal structures
Transcription Genetic Slug Apoptosis Ectoderm Chick Embryo Biology Transfection Models Biological SOXE Transcription Factors Epithelium General Biochemistry Genetics and Molecular Biology Mesoderm Mice medicine Animals rhoB GTP-Binding Protein FOXD3 Molecular Biology Embryonic Induction Mice Knockout Neural fold High Mobility Group Proteins Gene Expression Regulation Developmental Neural crest Forkhead Transcription Factors SOX9 Transcription Factor Cell Biology biology.organism_classification Cell biology DNA-Binding Proteins Repressor Proteins Neuroepithelial cell medicine.anatomical_structure Neural Crest embryonic structures Immunology Snail Family Transcription Factors Neural plate Transcription Factors Developmental Biology |
| Zdroj: | Developmental Cell. 8:179-192 |
| ISSN: | 1534-5807 |
| Popis: | SummaryTrunk neural crest cells are generated at the border between the neural plate and nonneural ectoderm, where they initiate a distinct program of gene expression, undergo an epithelial-mesenchymal transition (EMT), and delaminate from the neuroepithelium. Here, we provide evidence that members of three families of transcription induce these properties in premigratory neural crest cells. Sox9 acts to provide the competence for neural crest cells to undergo an EMT and is required for trunk neural crest survival. In the absence of Sox9, cells apoptose prior to or shortly after delamination. Slug/Snail, in the presence of Sox9, is sufficient to induce an EMT in neural epithelial cells, while FoxD3 regulates the expression of cell-cell adhesion molecules required for neural crest migration. Together, the data suggest a model in which a combination of transcription factors regulates the acquisition of the diverse properties of neural crest cells. |
| Databáze: | OpenAIRE |
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