Bioinformatics analysis of time series gene expression in left ventricle (LV) with acute myocardial infarction (AMI)
| Autor: | Xue Cao, Xueqi Li, Jin-Gang Liu, Tong Zhang, Shu-Jun Yan, Junyan Liu, Li-Chun Qi, Li-Li Zhao, Guo-Qian Wei |
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| Rok vydání: | 2013 |
| Předmět: |
ATF3
Time Factors Transcription Genetic medicine.drug_class Gene Expression Profiling Heart Ventricles ATF4 Activating transcription factor Myocardial Infarction Computational Biology General Medicine Biology Bioinformatics Andrology Gene expression Databases Genetic Genetics Natriuretic peptide medicine Humans Gene Regulatory Networks Gene Transcription factor Leukocyte Transendothelial Migration Pathway |
| Zdroj: | Gene. 543(2) |
| ISSN: | 1879-0038 |
| Popis: | This study is to investigate the key genes and their possible function in acute myocardial infarction (AMI). The data of GSE4648 downloaded from the Gene Expression Omnibus (GEO) database include 6 time points (15 min, 60 min, 4h, 12h, 24h and 48 h) of 12 left ventricle (LV) samples, 12 surviving LV free wall (FW) samples, 12 inter-ventricular septum (IVS) samples after AMI operation and corresponding sham-operated samples. The data of each sample were analyzed with Affy and Bioconductor packages, and differentially expressed genes (DEGs) were screened out using BETR package with false discovery rate (FDR) |
| Databáze: | OpenAIRE |
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