Role of Microrna-7 in Liver Diseases: A Comprehensive Review of the Mechanisms and Therapeutic Applications
| Autor: | Yanchao Jiang, Sen Han, Suthat Liangpunsakul, Nazmul Huda, Zhihong Yang, Ting Zhang, Praveen Kusumanchi |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Hepatitis RNA Untranslated Mechanism (biology) Liver Diseases General Medicine Biology medicine.disease MicroRNA 7 Article General Biochemistry Genetics and Molecular Biology Metastasis MicroRNAs 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Gene Expression Regulation 030220 oncology & carcinogenesis Hepatocellular carcinoma microRNA Gene expression Cancer research medicine Humans Steatosis |
| Zdroj: | J Investig Med |
| ISSN: | 1708-8267 1081-5589 |
| DOI: | 10.1136/jim-2020-001420 |
| Popis: | MicroRNA-7 (miR-7) is a small non-coding RNA, which plays critical roles in regulating gene expression of multiple key cellular processes. MiR-7 exhibits a tissue-specific pattern of expression, with abundant levels found in the brain, spleen, and pancreas. Although it is expressed at lower levels in other tissues, including the liver, miR-7 is involved in both the development of organs and biological functions of cells. In this review, we focus on the mechanisms by which miR-7 controls cell growth, proliferation, invasion, metastasis, metabolism, and inflammation. We also summarize the specific roles of miR-7 in liver diseases. MiR-7 is considered as a tumor suppressor miRNA in hepatocellular carcinoma and is involved in the pathogenesis of hepatic steatosis and hepatitis. Future studies to further define miR-7 functions and its mechanism in association with other types of liver diseases should be explored. An improved understanding from these studies will provide us a useful perspective leading to mechanism-based intervention by targeting miR-7 for the treatment of liver diseases. |
| Databáze: | OpenAIRE |
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