Myostatin promotes the terminal differentiation of embryonic muscle progenitors
| Autor: | Jerome Gros, Virginie Thomé, Alexandra C. McPherron, Marie Manceau, Bruce Paterson, Kathleen J. Savage, Christophe Marcelle |
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| Přispěvatelé: | Institut de Biologie du Développement de Marseille (IBDM), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: |
Cyclin-Dependent Kinase Inhibitor p21
Myoblasts Skeletal Cellular differentiation Population Mice Inbred Strains Chick Embryo Myostatin [SDV.BC]Life Sciences [q-bio]/Cellular Biology Biology Muscle Development MyoD Mice 03 medical and health sciences 0302 clinical medicine MyoD Protein Transforming Growth Factor beta Genetics medicine Animals Myocyte education Embryonic Stem Cells 030304 developmental biology 0303 health sciences education.field_of_study Skeletal muscle Cell Differentiation Embryo Mammalian musculoskeletal system Molecular biology Cell biology medicine.anatomical_structure GDF11 biology.protein 030217 neurology & neurosurgery Research Paper Developmental Biology |
| Zdroj: | Genes and Development Genes and Development, 2008, 22, pp.668-681 Genes and Development, Cold Spring Harbor Laboratory Press, 2008, 22, pp.668-681 |
| ISSN: | 0890-9369 |
| Popis: | Myostatin, a TGF-β family member, is an important regulator of adult muscle size. While extensively studied in vitro, the mechanisms by which this molecule mediates its effect in vivo are poorly understood. We addressed this question using chick and mouse embryos. We show that while myostatin overexpression in chick leads to an exhaustion of the muscle progenitor population that ultimately results in muscle hypotrophy, myostatin loss of function in chick and mouse provokes an expansion of this population. Our data demonstrate that myostatin acts in vivo to regulate the balance between proliferation and differentiation of embryonic muscle progenitors by promoting their terminal differentiation through the activation of p21 and MyoD. Previous studies have suggested that myostatin imposes quiescence on muscle progenitors. Our data suggest that myostatin’s effect on muscle progenitors is more complex than previously realized and is likely to be context-dependent. We propose a novel model for myostatin mode of action in vivo, in which myostatin affects the balance between proliferation and differentiation of embryonic muscle progenitors by enhancing their differentiation. |
| Databáze: | OpenAIRE |
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