U86, a novel snoRNA with an unprecedented gene organization in yeast
| Autor: | Irene Bozzoni, Elisa Caffarelli, Daniela Filippini, Fabiana Renzi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2001 |
| Předmět: |
Saccharomyces cerevisiae Proteins
intron RNA Splicing Xenopus Genes Fungal Molecular Sequence Data Biophysics Saccharomyces cerevisiae Xenopus Proteins Biology Biochemistry Homology (biology) Open Reading Frames 5′-top genes box c/d small nucleolar rnas nop56 gene processing splicing xenopus laevis Sequence Homology Nucleic Acid Gene cluster Animals Humans RNA Small Nucleolar Gene family Small nucleolar RNA Molecular Biology Gene Conserved Sequence Genetics Base Sequence urogenital system Intron Nuclear Proteins RNA-Binding Proteins Cell Biology Introns RNA splicing Small nuclear RNA |
| Popis: | The Xenopus laevis Nop56 gene (XNOP56), coding for a snoRNP-specific factor, belongs to the 5′-TOP gene family. XNOP56, as many 5′-TOP genes, contains an intron-encoded snoRNA. This previously unidentified RNA, named U86, was found as a highly conserved species in yeast and human. While in human it is also encoded in an intron of the hNop56 gene, in yeast it has an unprecedented gene organization: it is encoded inside an open-reading frame. Both in X. laevis and yeast, the synthesis of U86 snoRNA appears to be alternative to that of the cotranscribed mRNA. Despite the overall homology, the three U86 snoRNAs do not show strong conservation of the sequence upstream from the box D and none of them displays significant sequence complementarity to rRNA or snRNA sequences, suggesting a role different from that of methylation. |
| Databáze: | OpenAIRE |
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