Brain-derived neurotrophic factor is increased in serum levels of patients with symptomatic dermographism
| Autor: | Seval Erpolat, Huseyin Tugrul Celik, Bülent Bozkurt |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty lcsh:Internal medicine Dermatology 03 medical and health sciences Neurotrophic factors Internal medicine medicine lcsh:Dermatology Immunology and Allergy symptomatic dermographism Physical urticaria lcsh:RC31-1245 Brain-derived neurotrophic factor Original Paper biology medicine.diagnostic_test business.industry brain-derived neurotrophic factor neurotrophin Eosinophil lcsh:RL1-803 medicine.disease Pathophysiology Symptomatic dermographism 030104 developmental biology medicine.anatomical_structure Endocrinology Immunoassay biology.protein business Neurotrophin |
| Zdroj: | Advances in Dermatology and Allergology/Postȩpy Dermatologii i Alergologii Advances in Dermatology and Allergology, Vol 34, Iss 4, Pp 346-349 (2017) |
| ISSN: | 2299-0046 1642-395X |
| Popis: | Introduction: Symptomatic dermographism (SD) is the most common form of physical urticaria. However, the role of neuroimmune mechanisms in SD is unclear. Aim: To investigate circulating levels of brain-derived neurotrophic factor (BDNF) in symptomatic dermographism. Material and methods: Thirty-two patients suffering from SD and 33 healthy subjects were included in the study. Serum BDNF levels were determined by a human enzyme-linked immunoassay (ELISA) kit. The serum C-reactive protein concentration and eosinophil counts in peripheral blood were evaluated. Results: The BDNF serum levels were detectable in both SD patients and healthy controls. The BDNF serum levels were significantly higher in patients with SD compared with healthy controls (p = 0.004). There was a positive but weak correlation between serum BDNF and CRP levels; it was not statistically significant (r = 0.211, p = 0.255). There was also a positive but weak correlation between serum BDNF and eosinophil counts; it was not statistically significant (r = 0.271, p = 0.141). Conclusions: The present study shows that BDNF is increased in the serum levels of patients with SD, suggesting a role for BDNF in the pathophysiology of this disorder. |
| Databáze: | OpenAIRE |
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