Encapsulation of micronutrients resveratrol, genistein, and curcumin by folic acid-PAMAM nanoparticles
| Autor: | P. Chanphai, H. A. Tajmir-Riahi |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Dendrimers
Curcumin Clinical Biochemistry Genistein 02 engineering and technology Resveratrol 010402 general chemistry 01 natural sciences chemistry.chemical_compound Folic Acid Nanocapsules Dendrimer Micronutrients Solubility Molecular Biology food and beverages Cell Biology General Medicine 021001 nanoscience & nanotechnology 0104 chemical sciences Bioavailability Nylons chemistry Biochemistry Polyphenol 0210 nano-technology Nanoconjugates |
| Zdroj: | Molecular and cellular biochemistry. 449(1-2) |
| ISSN: | 1573-4919 |
| Popis: | It has been shown that encapsulation of dietary polyphenols leads to increased solubility and bioavailability of these micronutrients. The encapsulation of dietary polyphenols resveratrol, genistein, and curcumin by folic acid-PAMAM-G3 and folic acid-PAMAM-G4 nanoparticles was studied in aqueous solution at physiological conditions, using multiple spectroscopic methods, TEM images, and docking studies. The polyphenol bindings are via hydrophilic, hydrophobic, and H-bonding contacts with resveratrol forming more stable conjugates. As folic acid-PAMAM nanoparticle size increased, the loading efficacy and the stability of polyphenol-polymer conjugates were increased. Polyphenol encapsulation induced major alterations of dendrimer morphology. Folic acid-PAMAM nanoconjugates are capable of delivery of polyphenols in vitro. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink