General Anesthetic Exposure During Early Adolescence Persistently Alters Ethanol Responses
| Autor: | David F. Werner, Jonathan K. Gore-Langton, Elena I. Varlinskaya, Justine D. Landin, Linda P. Spear |
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| Rok vydání: | 2019 |
| Předmět: |
Male
Exacerbation Adolescent Alcohol Drinking medicine.drug_class Early adolescence Anesthetics General 030508 substance abuse Medicine (miscellaneous) Physiology Alcohol Alcohol use disorder Toxicology Article Hypnotic Rats Sprague-Dawley 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Risk Factors mental disorders medicine Animals Humans Social Behavior Memory Disorders Ethanol Isoflurane business.industry medicine.disease Rats Psychiatry and Mental health Alcoholism chemistry Anesthetic 0305 other medical science business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Alcohol Clin Exp Res |
| ISSN: | 1530-0277 |
| Popis: | BACKGROUND: Adolescent alcohol abuse can lead to behavioral dysfunction and chronic, relapsing alcohol use disorder (AUD) in adulthood. However, not all adolescents that consume alcohol will develop an AUD, therefore it is critical to identify neural and environmental risk factors that contribute to increases in susceptibility to AUDs following adolescent alcohol (ethanol) exposure. We previously found that adolescent anesthetic exposure led to strikingly similar behavioral and neural effects as adolescent alcohol exposure. Therefore, we tested the hypothesis that general anesthetic exposure during early adolescence would alter ethanol responses consistent with an exacerbation of the adolescent alcohol phenotype. METHODS: To test this hypothesis, early adolescent male Sprague-Dawley rats were exposed for a short duration to the general anesthetic isoflurane and tested on multiple ethanol-induced behaviors in mid-late adolescence or adulthood. RESULTS: Adolescent rats exposed to isoflurane exhibited decreases in sensitivity to negative properties of ethanol such as its aversive, hypnotic, and socially suppressive effects, as well as increases in voluntary ethanol intake and cognitive impairment. Select behaviors were noted to persist into adulthood following adolescent isoflurane exposure. Similar exposure in adults had no effects on ethanol sensitivity. CONCLUSIONS: This study demonstrates for the first time that early adolescent isoflurane exposure alters ethanol sensitivity in a manner consistent with an exacerbation of adolescent-typical alcohol responding. These findings suggest that general anesthetic exposure during adolescence may be an environmental risk factor contributing to an enhanced susceptibility to developing AUDs in an already vulnerable population. |
| Databáze: | OpenAIRE |
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