Health-related quality of life varies in different respiratory disorders: a multi-case control population based study
| Autor: | Gianfranco Di Gennaro, Luigi Perbellini, Silvia Sembeni, Maria Elisabetta Zanolin, Morena Nicolis, Roberto de Marco, Cristina Bombieri, Alessandro Marcon, Veronica Cappa, Marcello Ferrari, Liliya Chamitava, Francesco Spelta, Lucia Cazzoletti |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Pulmonary and Respiratory Medicine Quality of life medicine.medical_specialty Chronic bronchitis Allergy Population Severity of Illness Index Population control Pulmonary Disease Chronic Obstructive 03 medical and health sciences 0302 clinical medicine Surveys and Questionnaires Internal medicine Hypersensitivity medicine Humans COPD 030212 general & internal medicine Respiratory system education Asthma lcsh:RC705-779 education.field_of_study business.industry Clinical epidemiology lcsh:Diseases of the respiratory system Middle Aged medicine.disease humanities Italy 030228 respiratory system Case-Control Studies Female business Research Article |
| Zdroj: | BMC Pulmonary Medicine BMC Pulmonary Medicine, Vol 19, Iss 1, Pp 1-8 (2019) |
| Popis: | Background and objective Health-related quality of life (HRQL) in respiratory diseases has been generally investigated in clinical settings, focusing on a single disorder. In this study on a general population sample, we assessed the relationship between HRQL and several respiratory diseases studied simultaneously (COPD, current (CA) and past (PA) asthma, allergic (AR) and non-allergic (NAR) rhinitis and chronic bronchitis (CB). Methods Controls (n = 328) and cases of NAR (n = 95), AR (n = 163), CB (n = 48), CA (n = 224), PA (n = 126) and COPD (n = 28) were recruited in the centre of Verona in the frame of the Italian multi-case control GEIRD (Gene Environment Interactions in Respiratory Diseases) study; HRQL was measured through the SF-36 questionnaire. The relationships between HRQL (in terms of Physical (PCS) and Mental Component Scores (MCS)), respiratory diseases, and covariates were evaluated. Results With respect to controls, the adjusted PCS median score was worse in subjects suffering from current asthma (− 1.7; 95%CI:-2.8;-0.6), CB (− 3.8; 95%CI:-5.7;-1.9), and COPD (− 5.6; 95%CI:-8.1;-3.1). MCS was worse in current asthmatics (− 2.2; 95%CI:-4.1;-0.3), CB (− 5.5; 95%CI:-8.7;-2.2), and COPD cases (− 4.6; 95%CI:-8.8;-0.5) as well. Conclusions To our knowledge, this is the first study in the general population that analyzed HRQL performing a simultaneous comparison of HRLQ in several respiratory disorders. We found that subjects suffering from COPD, CA, and CB had the poorest HRQL. Clinicians should carefully consider the possible impact of respiratory disorders as CB and not only that of CA and COPD. Electronic supplementary material The online version of this article (10.1186/s12890-019-0796-8) contains supplementary material, which is available to authorized users. |
| Databáze: | OpenAIRE |
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