Diastolic hypotension in pediatric patients with asthma receiving continuous albuterol
| Autor: | S. Shahrukh Hashmi, Cheryl L. Samuels, Ricardo A. Mosquera, Shannan Eades, Sarah Wisecup |
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| Rok vydání: | 2015 |
| Předmět: |
Pulmonary and Respiratory Medicine
Diastolic hypotension Male Percentile Status Asthmaticus Blood Pressure Positive correlation Severity of Illness Index law.invention Sex Factors Interquartile range law Risk Factors medicine Immunology and Allergy Humans Albuterol Child Asthma Retrospective Studies Dose-Response Relationship Drug business.industry Nebulizers and Vaporizers Age Factors Infant Retrospective cohort study medicine.disease Intensive care unit Bronchodilator Agents Anesthesia Child Preschool Pediatrics Perinatology and Child Health Fluid Therapy Female Hypotension business Intermediate care |
| Zdroj: | The Journal of asthma : official journal of the Association for the Care of Asthma. 52(7) |
| ISSN: | 1532-4303 |
| Popis: | Concerns have been raised regarding cardiac side effects of continuous high-dose albuterol nebulization in status asthmaticus management. Our study goal was to determine prevalence and potential risk factors for hypotension development during continuous albuterol administration in pediatric patients.A retrospective cohort study was conducted at Children's Memorial Hermann Hospital from 1 January 2011 to 31 August 2012. A total of 152 patients admitted to pediatric intensive or intermediate care units who received continuous albuterol nebulization for management of status asthmaticus were analyzed.Diastolic hypotension, defined as a value50 mmHg or5th percentile of normal for age, developed in 90% of patients and a positive correlation with increasing doses of albuterol was demonstrated. The overall median time to onset of hypotension was 4 h (interquartile range (IQR): 2-6.5) and was significantly lower among patients admitted to the intensive care unit rather than intermediate care (p = 0.005). The odds of hypotension were 82% lower among patients who received fluid boluses prior to continuous albuterol nebulization. None of the potential risk factors demonstrated statistical significance.Diastolic hypotension is a common occurrence among patients who receive continuous albuterol nebulization for status asthmaticus. Total albuterol dose appeared to be directly related to risk of developing diastolic hypotension. Administration of supplemental fluid boluses before continuous nebulized albuterol appeared to provide a significant protective effect. The clinical impact and the significance of diastolic hypotension and the importance of prophylactic administration of intravenous fluid boluses in patients experiencing status asthmaticus are yet to be determined. |
| Databáze: | OpenAIRE |
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