The Effect of Bolus Vitamin D3 Supplementation on Distal Radius Fracture Healing: A Randomized Controlled Trial Using HR‐pQCT

Autor: P. Geusens, S.G.P. Bours, Jacobus J. Arts, J.J.A. de Jong, J. van den Bergh, B. van Rietbergen, Frans Heyer, Martijn Poeze, Paul C. Willems, S. M. J. van Kuijk, Judith A P Bons
Přispěvatelé: RS: NUTRIM - R3 - Respiratory & Age-related Health, RS: MHeNs - R3 - Neuroscience, Beeldvorming, RS: CAPHRI - R3 - Functioning, Participating and Rehabilitation, Orthopedie, MUMC+: MA Orthopedie (9), MUMC+: MA Reumatologie (9), RS: CAPHRI - R5 - Optimising Patient Care, RS: CAPHRI - R2 - Creating Value-Based Health Care, Epidemiologie, MUMC+: KIO Kemta (9), MUMC+: DA CDL Algemeen (9), Surgery, MUMC+: MA Heelkunde (9), MUMC+: NAZL en ROAZ (9), Interne Geneeskunde, Orthopaedic Biomechanics
Jazyk: angličtina
Rok vydání: 2021
Předmět:
0301 basic medicine
Vitamin
medicine.medical_specialty
Bone density
Endocrinology
Diabetes and Metabolism
Population
Urology
030209 endocrinology & metabolism
Bone healing
SDG 3 – Goede gezondheid en welzijn
Bone resorption
CALCIUM
PARAMETERS
Bone remodeling
03 medical and health sciences
chemistry.chemical_compound
D DEFICIENCY
0302 clinical medicine
Radius/diagnostic imaging
SDG 3 - Good Health and Well-being
Bone Density
medicine
Vitamin D and neurology
Humans
Orthopedics and Sports Medicine
Quantitative computed tomography
Vitamin D
education
Cholecalciferol
REPAIR
Fracture Healing
education.field_of_study
medicine.diagnostic_test
RECEPTOR
business.industry
QUANTITATIVE COMPUTED-TOMOGRAPHY
WOMEN
PREVENTION
Clinical Trial
Radius
030104 developmental biology
chemistry
Dietary Supplements
BONE-DENSITY
Female
business
Cholecalciferol/pharmacology
Zdroj: Journal of Bone and Mineral Research
Journal of Bone and Mineral Research, 36(8), 1492-1501. Wiley
Journal of Bone and Mineral Research, 36(8), 1492-1501. Wiley-Blackwell
ISSN: 1523-4681
0884-0431
Popis: Vitamin D is an important factor in bone metabolism. Animal studies have shown a positive effect of vitamin D-3 supplementation on fracture healing, but evidence from clinical trials is inconclusive. A randomized controlled trial was performed to assess the effects of vitamin D-3 supplementation on fracture healing using HR-pQCT-based outcome parameters. Thirty-two postmenopausal women with a conservatively treated distal radius fracture were included within 2 weeks postfracture and randomized to a low-dose (N = 10) and a high-dose (N = 11) vitamin D intervention group receiving a 6-week bolus dose, equivalent to 700 and 1800 IU vitamin D-3 supplementation per day, respectively, in addition to a control group (N = 11) receiving no supplementation. After the baseline visit 1-2 weeks postfracture, follow-up visits were scheduled at 3-4, 6-8, and 12 weeks postfracture. At each visit, HR-pQCT scans of the fractured radius were performed. Cortical and trabecular bone density and microarchitectural parameters and microfinite element analysis-derived torsion, compression, and bending stiffness were assessed. Additionally, serum markers of bone resorption (CTX) and bone formation (PINP) were measured. Baseline serum levels of 25OHD(3) were
Databáze: OpenAIRE
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