Persistent luminescence-polypyrrole nanocomposite for dual-modal imaging and photothermal therapy of mammary cancer
| Autor: | Weihang Ding, Lianbing Zhang, Letong Xu, Yang Li, Shuqi Wu, Ruofei Zhang, Kelong Fan |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Luminescence
Biocompatibility Photothermal Therapy Polymers Photoacoustic imaging in biomedicine Breast Neoplasms Nanotechnology 02 engineering and technology Polypyrrole 01 natural sciences Theranostic Nanomedicine Nanocomposites Analytical Chemistry chemistry.chemical_compound Persistent luminescence Cell Line Tumor medicine Humans Pyrroles Nanocomposite 010401 analytical chemistry Cancer Phototherapy Photothermal therapy 021001 nanoscience & nanotechnology medicine.disease 0104 chemical sciences chemistry Nanoparticles 0210 nano-technology Pl quenching |
| Zdroj: | Talanta. 221:121435 |
| ISSN: | 0039-9140 |
| Popis: | Multifunctional nanocomposites that possess imaging and high-performance therapeutic features are experiencing a surge in interest in the precision clinical anticancer treatment. In this work, we reported the fabrication and bio-application of a novel persistent luminescence-polypyrrole nanocomposite (LPLNP@SPP) for photoacoustic/persistent luminescence (PA/PL) dual-modal imaging guided photothermal therapy (PTT). The construction of LPLNP@SPP avoids the PL quenching of LPLNP-OH by the polypyrrole-coating, and thus enables the combination of PL and PTT. The LPLNP@SPP shows excellent biocompatibility, long lasting near-infrared (NIR) PL emitting without in situ excitation and high-contrast PA signals. Meanwhile, this nanocomposite exhibits strong NIR absorbance and exceptional photothermal conversion capability, which provides notable potential for imaging-guided antitumor therapy. Thus, our work highlights the dual-functional core-shell LPLNP@SPP as a feasible theranostic nanoplatform for cancer diagnosis and therapy. |
| Databáze: | OpenAIRE |
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