Double mild stimulation and egg collection in the same cycle for management of poor ovarian responders
| Autor: | Tahereh Madani, Mandana Hemat, Arezoo Arabipoor, Zahra Zolfaghari, Shabnam Khodabakhshi |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
endocrine system medicine.medical_specialty medicine.medical_treatment Oocyte Retrieval Stimulation Fertilization in Vitro Luteal phase Luteal Phase Intracytoplasmic sperm injection Clomiphene 03 medical and health sciences 0302 clinical medicine Human fertilization Embryo cryopreservation Ovulation Induction Follicular phase medicine Humans Prospective Studies Sperm Injections Intracytoplasmic Mild stimulation Gynecology 030219 obstetrics & reproductive medicine business.industry Letrozole Obstetrics and Gynecology Fertility Agents Female Embryo Transfer Reproductive Medicine Follicular Phase 030220 oncology & carcinogenesis Fertilization Female business medicine.drug |
| Zdroj: | Journal of gynecology obstetrics and human reproduction. 48(5) |
| ISSN: | 2468-7847 |
| Popis: | To evaluate the effect of double stimulations during the follicular and luteal phases in women with poor ovarian response (POR) in in-vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) cycles.This prospective clinical study was performed in Royan Institute from October 2014 to January 2016. 121 patients were diagnosed as POR on the basis of Bologna criteria were included. Double stimulations were performed during the follicular and luteal phases by Letrozole, Clomid, hMG and GnRH-agonist. The patients' present cycle outcomes were compared with those of the previous cycle results using appropriate statistical tests.The total of 104 (85.9%) patients completed the stimulation stages. The analysis revealed the number of retrieved oocytes after the first and second stimulations did not differ (P = 0.2); however, the fertilization rate and the number of frozen embryos after the first stimulation were significantly higher than those of in the second stimulation (P 0.001 and P = 0.03), indicating the better quality of retrieved oocytes after the first stimulation. The mean number of MII oocytes and the fertilization rate after Shanghai protocol were higher than those of the previous antagonist protocol with a substantial trend toward significance (P = 0.06), which can be clinically important. The cancellation rate (33%) due to no ovarian response and no embryo formation was still high in these patients.Since the intensity of stimulation in both stages was mild, this protocol can be considered a time-efficient and patient friendly regime; however, more studies are required with emphasis on its cost-effectiveness. |
| Databáze: | OpenAIRE |
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