Supplementary Figures 1 - 4 from Anti-CTLA-4 Antibodies of IgG2a Isotype Enhance Antitumor Activity through Reduction of Intratumoral Regulatory T Cells

Autor: Alan J. Korman, Mohan Srinivasan, Timothy Chen, Karla A. Henning, Michael Quigley, John J. Engelhardt, Mark J. Selby
Rok vydání: 2023
Popis: PDF file - 206K, Supplemental Figure S1. Equivalent binding of anti-CTLA-4 isotypes to cell surface CTLA-4. Supplemental Figure S2. Serum concentrations of anti-CTLA-4 isotypes in C57BL/6 mice. Supplemental Figure S3. Representative FACS plots for peripheral regulatory T cells. Supplemental Figure S4. A. Representative FACS plots for intratumoral regulatory T cells. B. Kinetics of intratumoral Treg reduction following anti-CTLA-4 treatment. Supplemental Figure S5. Isotype-dependent recruitment of MDSCs and IL-1α production.
Databáze: OpenAIRE