Sirolimus versus paclitaxel-eluting stents in small coronary vessels: long-term outcomes from a single-center registry
| Autor: | Corrado Tamburino, Claudia Tamburino, Giorgio Conti, Rita Bucalo, Davide Capodanno, Cettina Ruperto, Piera Capranzano, Alessandra Sanfilippo, Anna Caggegi, Anita Blundo |
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| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Male
medicine.medical_specialty Paclitaxel medicine.medical_treatment Antineoplastic Agents Coronary Artery Disease Single Center Internal medicine Humans Medicine Myocardial infarction Adverse effect Aged Retrospective Studies Sirolimus business.industry Stent Drug-Eluting Stents Retrospective cohort study Organ Size General Medicine Middle Aged medicine.disease Coronary Vessels Thrombosis Treatment Outcome Cardiology Female Observational study Cardiology and Cardiovascular Medicine business medicine.drug |
| Popis: | Objective Several studies showed that small vessel diameter is a determinant of increased risk of adverse events after stenting. The efficacy of different drug-eluting stent types implanted in small vessels has still not been established. The aim of the present observational study was to compare long-term clinical outcomes after sirolimus-eluting stent (SES) or paclitaxel-eluting stent (PES) implantation in lesions located in small coronary vessels. Methods For the purpose of this analysis patients undergoing SES or PES implantation in vessels with diameter 2.5 mm or less, from May 2002 to December 2006, were included. Long-term rates of major adverse cardiac events were evaluated and compared between the two groups. Independent predictors of major adverse cardiac events were also investigated. Results A total of 336 patients were included, 225 were treated only with SES and 111 only with PES. During a mean follow-up of 23.3 +/- 12.1 months the major adverse cardiac events rates were 12.8 versus 13.6%, P = 0.98 in SES versus PES groups, respectively. The rates of target lesion revascularization (8.0 versus 6.3%, P = 0.75), mortality (3.5 versus 4.5%, P = 0.88) and myocardial infarction (2.6 versus 4.5%, P = 0.41) were similar between SES and PES, respectively. The overall thrombosis rate was also not significantly different in SES and PES groups (1.3% SES versus 4.5% PES, P = 0.12). Conclusion In this study SES and PES provided similar long-term results after treatment of lesions in small vessels. Nevertheless, larger randomized studies are needed to confirm these findings. |
| Databáze: | OpenAIRE |
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