Novel 12-Membered Ring Macrolides with Activity against Erythromycin-resistant Organisms
| Autor: | Zhenkun Ma, Peter A. Nemoto, Xiaolin Zhang, Stevan W. Djuric |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Pharmacology
chemistry.chemical_classification Staphylococcus aureus medicine.drug_class Streptococcus pyogenes Desosamine Stereochemistry Antibiotics Erythromycin General Medicine Microbial Sensitivity Tests Ring (chemistry) Haemophilus influenzae Anti-Bacterial Agents chemistry.chemical_compound chemistry Drug Resistance Bacterial Drug Discovery medicine Lactone medicine.drug |
| Zdroj: | The Journal of Antibiotics. 56:392-398 |
| ISSN: | 1881-1469 0021-8820 |
| DOI: | 10.7164/antibiotics.56.392 |
| Popis: | A series of novel 12-membered ring macrolides was designed based on available information on structure-activity relationships and macrolide-ribosome interactions. Compounds with the desosamine and the anchor group properly attached to the 12-membered lactone ring exhibited improved activity against erythromycin-resistant organisms. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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