Local glycosaminoglycan polysulphate injection therapy in osteoarthritis of the hand. A placebo-controlled clinical study
| Autor: | M Marklund, O Pastinen, B Forsskåhl |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.medical_treatment Immunology Osteoarthritis Placebo law.invention Injections Intra-Articular Route of administration Rheumatology Randomized controlled trial Double-Blind Method law medicine Immunology and Allergy Humans Aged Glycosaminoglycans Chemotherapy Clinical Trials as Topic business.industry General Medicine Middle Aged medicine.disease Hand Surgery Clinical trial Menopause medicine.anatomical_structure Anesthesia Upper limb Female business Follow-Up Studies |
| Zdroj: | Scandinavian journal of rheumatology. 17(3) |
| ISSN: | 0300-9742 |
| Popis: | In this placebo-controlled double-blind trial in 30 patients suffering from disabling osteoarthritis of the hand, the long-term effect of periarticular injections of glycosaminoglycan polysulphate (GAGPS) on symptoms, hand function and life quality was investigated. The overall effect of the half-year follow-up was clinically good in 46% of the GAGPS-treated cases, compared with 14% of the controls. Significant differences in grip- and pinch strength were also found between the treatment groups. Significant differences were still seen at the one-year follow-up, as 13 patients (87%) in the GAGPS group reported improvement in their most restricted activity, compared with 6 (43%) of the controls. Nine periarticular injections of GAGPS over a period of 13 weeks gave a clinically good and long-lasting effect, with improved life quality for most of the patients. |
| Databáze: | OpenAIRE |
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