Relationship Between Renal Hemodynamics and Urinary Type IV Collagen in Patients with Essential Hypertension

Autor:	Jun Irita, Jitsuo Higaki, Tomoaki Nagao, Daijiro Enomoto, Ken-ichi Miyoshi, Masanori Jotoku, Takafumi Okura
Rok vydání:	2012
Předmět:	Adult Collagen Type IV Male medicine.medical_specialty Physiology Urinary system Urology Hemodynamics Kidney Essential hypertension Type IV collagen chemistry.chemical_compound Risk Factors Internal medicine Internal Medicine medicine Humans Diabetic Nephropathies Renal Insufficiency Chronic Aged Analysis of Variance Creatinine business.industry Glomerulosclerosis General Medicine Middle Aged Interlobar arteries medicine.disease medicine.anatomical_structure Endocrinology chemistry Hypertension Vascular resistance Regression Analysis Female Vascular Resistance business
Zdroj:	Clinical and Experimental Hypertension. 34:612-616
ISSN:	1525-6006 1064-1963
DOI:	10.3109/10641963.2012.683911
Popis:	Urinary type IV collagen excretion (uT4C) in diabetic patients is higher than in normal subjects. In this study, we investigated the relationship between uT4C and renal hemodynamics in 42 patients with essential hypertension. The renal resistive index (RI) is calculated from blood flow velocities measured using pulsed-wave in interlobar arteries. There was a significant correlation between uT4C to creatinine ratio (uT4C/uCr) and age, hemoglobin A1c (HbA1c), and RI. A stepwise regression analysis showed that RI was independently associated with uT4C/uCr. These results indicated that uT4C may be a marker of renovascular stiffness due to glomerulosclerosis in patients with essential hypertension.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2ec4348df7dece5308e1aaa067f4c66 https://doi.org/10.3109/10641963.2012.683911 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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