Pseudoxanthoma Elasticum-Like in β-Thalassemia Major, a matter of α-Klotho and Parathyroid Hormone?
| Autor: | Gian Luca Forni, Cristina Malaventura, Andrea Giusti, Cristina Bosi, Alessandro Baldan, Caterina Borgna-Pignatti |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male 0301 basic medicine medicine.medical_specialty Clinical Biochemistry chemistry.chemical_element Parathyroid hormone 030204 cardiovascular system & hematology Calcium parathyroid hormone (PTH) NO Pathogenesis 03 medical and health sciences 0302 clinical medicine Internal medicine pseudoxanthoma elasticum-like (PXL) α-Klotho β-thalassemia major (β-TM) Hematology Genetics (clinical) Biochemistry (medical) medicine Humans Pseudoxanthoma Elasticum Klotho Proteins Klotho Glucuronidase business.industry beta-Thalassemia Middle Aged α klotho Pseudoxanthoma elasticum medicine.disease 030104 developmental biology Endocrinology chemistry Parathyroid Hormone Arterial blood Female business |
| DOI: | 10.6084/m9.figshare.5688001 |
| Popis: | Pseudoxanthoma elasticum-like (PXL) condition is one of the complications faced by patients with β-thalassemia major (β-TM). Histopathological features include abnormal, mineralized and fragmented elastic fibers in skin, eyes and arterial blood vessels (elastorrhexia). The pathogenesis of PXL lesions in β-TM is not yet completely understood. This study was aimed at analyzing a possible implication of α-Klotho in the clinical manifestation of PXL in patients with β-TM (30 with and 78 without PXL). A significant correlation was observed between Klotho, parathyroid hormone (PTH) and serum calcium (Ca). Our analysis seems to indicate α-Klotho and PTH as factors that can affect the development of PXL. |
| Databáze: | OpenAIRE |
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