Interventional stem cell therapy
| Autor: | Charles A. Gilliland, Tatiana Chadid, Zhenghong Lee, M. Hawkins, Paul Harkey, Raghavan Chinnadurai, Luke P. Brewster, J. Prologo |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Pathology medicine.medical_specialty medicine.diagnostic_test business.industry medicine.medical_treatment Interventional radiology General Medicine Stem-cell therapy Radiology Interventional 030204 cardiovascular system & hematology Bioinformatics Cell therapy 03 medical and health sciences Paracrine signalling 030104 developmental biology 0302 clinical medicine medicine Systemic administration Humans Radiology Nuclear Medicine and imaging Stem cell business Site of action Stem Cell Transplantation |
| Zdroj: | Clinical Radiology. 71:307-311 |
| ISSN: | 0009-9260 |
| DOI: | 10.1016/j.crad.2016.01.005 |
| Popis: | The ability to deliver cells in appropriate doses to their targeted site of action is a well-known obstacle to optimising stem cell therapy. Systemic administration of cells results in pulmonary "trapping," which significantly decreases the number of available circulating cells to impact underlying disorders. Directed delivery of stem cells in interventional radiology may provide an additional option for bypassing the lungs, as well as introduce novel potential avenues for decreasing doses required to effect cellular therapy, efficiently obtain local paracrine effects, and/or to simplify targeting strategies. |
| Databáze: | OpenAIRE |
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