Prognostic value of polygenic risk scores for adults with psychosis
Autor: | Paul F. O'Reilly, Steven A. McCarroll, Mark Hyman Rapaport, Noam D. Beckmann, Eric D. Achtyes, Dolores Malaspina, Ruth J. F. Loos, Michele T. Pato, Gillian M. Belbin, Liam Cotter, Alexander W. Charney, Michael Preuss, Carlos N. Pato, Benjamin S. Glicksberg, Ayman H. Fanous, Deepak Kaji, Eimear E. Kenny, Peter F. Buckley, Douglas S. Lehrer, Tim B. Bigdeli, Tielman Van Vleck, Isotta Landi, Girish N. Nadkarni, Eric E. Schadt |
---|---|
Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
Adult
Male medicine.medical_specialty Psychosis Multifactorial Inheritance MEDLINE Disease General Biochemistry Genetics and Molecular Biology Article Risk Factors Medicine Humans Genetic Predisposition to Disease business.industry General Medicine Middle Aged medicine.disease Prognosis Psychotic Disorders Schizophrenia Predictive power Medical genetics Polygenic risk score Female Psychiatric interview business Clinical psychology Genome-Wide Association Study |
Zdroj: | Nat Med |
Popis: | Polygenic risk scores (PRS) summarize genetic liability to a disease at the individual level, and the aim is to use them as biomarkers of disease and poor outcomes in real-world clinical practice. To date, few studies have assessed the prognostic value of PRS relative to standards of care. Schizophrenia (SCZ), the archetypal psychotic illness, is an ideal test case for this because the predictive power of the SCZ PRS exceeds that of most other common diseases. Here, we analyzed clinical and genetic data from two multi-ethnic cohorts totaling 8,541 adults with SCZ and related psychotic disorders, to assess whether the SCZ PRS improves the prediction of poor outcomes relative to clinical features captured in a standard psychiatric interview. For all outcomes investigated, the SCZ PRS did not improve the performance of predictive models, an observation that was generally robust to divergent case ascertainment strategies and the ancestral background of the study participants. The inclusion of polygenic risk scores does not improve the performance of standard-of-care predictive models of disease outcomes in patients with psychosis. |
Databáze: | OpenAIRE |
Externí odkaz: |