Efficacy of Exercise Interventions in Patients with Acute Leukemia: A Meta-Analysis
| Autor: | Xiangguang Yin, Jinjie Zhu, Zejuan Gu, Yuan Zhou |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Myeloid
Physical fitness Emotions lcsh:Medicine Social Sciences Anxiety Pathology and Laboratory Medicine 0302 clinical medicine Mathematical and Statistical Techniques Medicine and Health Sciences Psychology Public and Occupational Health 030212 general & internal medicine lcsh:Science Fatigue Randomized Controlled Trials as Topic Acute leukemia Multidisciplinary Sports Science Exercise Therapy Leukemia Leukemia Myeloid Acute medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis Meta-analysis Strength Training Physical Sciences medicine.symptom Statistics (Mathematics) Research Article medicine.medical_specialty Strength training MEDLINE Research and Analysis Methods 03 medical and health sciences Signs and Symptoms Complementary and Alternative Medicine Diagnostic Medicine Internal medicine medicine Cancer Detection and Diagnosis Humans Sports and Exercise Medicine Statistical Methods Exercise business.industry lcsh:R Biology and Life Sciences Physical Activity medicine.disease Physical Fitness Physical therapy lcsh:Q business Mathematics Meta-Analysis |
| Zdroj: | PLoS ONE PLoS ONE, Vol 11, Iss 7, p e0159966 (2016) |
| ISSN: | 1932-6203 |
| Popis: | Background Decreased physical performance and impaired physiological and psychological fitness have been reported in patients with acute leukemia (AL). We performed a meta-analysis to assess the efficacy of exercise in patients with AL. Methods In this meta-analysis, the electronic databases MEDLINE, Embase, Cochrane, Web of Science, SPORTDiscus, CINAHL and PEDro were searched through November 2015. Three authors participated in the study selection, data extraction and quality assessment. The instrument used for quality assessment was derived from the Cochrane Handbook for Systematic Reviews of Interventions. Analyses were performed according to the recommendations of The Cochrane Collaboration using Review Manager 5.3. Results Nine trials (8 randomized controlled trials and 1 quasi-experimental design trial) with 314 AL participants were included in this meta-analysis. The pooled standardized mean differences between the exercise and control groups were 0.45 (95% confidence interval (CI): 0.09 to 0.80, P value = 0.01, P for heterogeneity = 0.23, I2 = 28%) for cardiorespiratory fitness and 0.67 (95% CI: 0.28 to 1.06, P value = 0.0007, P for heterogeneity = 0.14, I2 = 43%) for muscle strength. Based on the data for fatigue, anxiety, and depression, there were no significant differences in these parameters between the exercise and control groups. Conclusions Exercise has beneficial effects on cardiorespiratory fitness, muscle strength and functional mobility; however, no significant improvements in fatigue, anxiety, depression or quality of life were observed. Further large-scale randomized trials are needed to assess the safety, feasibility and efficacy of exercise programs for AL patients. |
| Databáze: | OpenAIRE |
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