Brain-derived neurotrophic factor correlates with functional and cognitive impairment in non-disabled older individuals
| Autor: | Mari Carmen Mascaros, Elena Torralba-Martínez, Julio Fernández-Garrido, Omar Cauli, Rut Navarro-Martínez, Yolanda Verdejo, Mary Martinez-Martinez, Cristina Buigues |
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| Rok vydání: | 2015 |
| Předmět: |
Oncology
Male Aging medicine.medical_specialty Activities of daily living Frail Elderly Neuropsychological Tests Biochemistry Endocrinology Cognition Neurotrophic factors Internal medicine Neuroplasticity Activities of Daily Living Genetics Medicine Humans Psychiatry Molecular Biology Geriatric Assessment Aged Brain-derived neurotrophic factor Aged 80 and over Mini–Mental State Examination medicine.diagnostic_test business.industry Brain-Derived Neurotrophic Factor Cell Biology Middle Aged Pathophysiology Cross-Sectional Studies Spain Linear Models Biomarker (medicine) Female business Cognition Disorders Biomarkers |
| Zdroj: | Experimental gerontology. 72 |
| ISSN: | 1873-6815 |
| Popis: | We used a complete battery of geriatric and psychometric tests to evaluate whether plasma-borne brain-derived neurotrophic factor (BDNF), a master molecule in neuroplasticity, is associated with the severity of functional and cognitive impairment in non-disabled older individuals. There was a significant positive correlation between BDNF plasma concentrations and the Barthel index, a measurement of the ability of individuals to perform the activities of daily living (p=0.03) and the concentration subcategory measured with the mini mental state examination (MMSE) test (p = 0.01). Furthermore, plasma BDNF inversely and significantly correlated with the blood eosinophil count (p = 0.01), the total cholesterol concentration (p = 0.04), and high-density lipoprotein cholesterol (p=0.04). However, BDNF did not correlate with any other socio-demographic or clinical characteristics, other analytical parameters measured in the blood, or any other geriatric assessment scales. Our results suggest that BDNF may play a role in the pathophysiology of functional impairment in the elderly and in some aspects of cognitive function. However, more studies are needed to understand the relationship between circulating BDNF and functional impairment to determine if BDNF represents a candidate biomarker for this type of cognitive impairment. |
| Databáze: | OpenAIRE |
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