Chloroquine does not enhance the activity of clarithromycin against multiplication of Mycobacterium avium within human macrophages
| Autor: | J Grosset, Jean-Louis Vildé, J. J. Pocidalo, C Perronne, T. Lazard, C Truffot-Pernot |
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| Rok vydání: | 1994 |
| Předmět: |
Pulmonary and Respiratory Medicine
medicine.drug_class Immunology Antibiotics Colony Count Microbial Microbiology Mycobacterium tuberculosis Minimum inhibitory concentration Chloroquine Clarithromycin polycyclic compounds medicine Humans Drug Interactions Cells Cultured biology Chemistry Macrophages biochemical phenomena metabolism and nutrition bacterial infections and mycoses Coxiella burnetii biology.organism_classification Intracellular Mycobacterium avium medicine.drug Mycobacterium |
| Zdroj: | Tubercle and Lung Disease. 75:283-285 |
| ISSN: | 0962-8479 |
| DOI: | 10.1016/0962-8479(94)90133-3 |
| Popis: | Chloroquine, an alkalinizing lysosomotropic agent, enhances the intracellular activity of antibiotics against Mycobacterium tuberculosis or Coxiella burnetii.To determine if chloroquine modifies the activity of clarithromycin, less effective at acidic pH, against intracellular Mycobacterium avium.The activity of clarithromycin (4 micrograms/ml) against the MO-1 strain of M. avium was evaluated within human macrophages in presence of chloroquine (5 micrograms/ml). The minimal inhibitory concentration of clarithromycin for the strain was 2 micrograms/ml.While clarithromycin alone did decrease the intracellular infection at day 7 of culture (P0.01), chloroquine alone did not impede the intracellular growth of M. avium, and did not enhance the activity of clarithromycin.Chloroquine should not improve clarithromycin treatment against M. avium infection. |
| Databáze: | OpenAIRE |
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