Evidence for a T-lymphocyte dependent mechanism involving proinflammatory cytokines in anticonvulsant hypersensitivity syndrome: a case report
| Autor: | Elena Chiappini, Luisa Galli, Calabri Gb, M. Peruzzi, M. De Martino |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Drug
medicine.medical_treatment media_common.quotation_subject Immunology Pharmacology Proinflammatory cytokine 03 medical and health sciences 0302 clinical medicine medicine Immunology and Allergy Interleukin 6 media_common biology business.industry medicine.disease In vitro Anticonvulsant Drug Hypersensitivity Syndrome Anticonvulsant hypersensitivity syndrome 030220 oncology & carcinogenesis biology.protein Phenobarbital business 030215 immunology medicine.drug |
| Zdroj: | Europe PubMed Central Scopus-Elsevier |
| ISSN: | 2058-7384 |
| Popis: | The anticonvulsant drug hypersensitivity syndrome (AHS) is a potentially fatal drug reaction associated with aromatic antiepileptic drugs, the pathogenic mechanisms of which are still unclear. We studied a 2-year-old female affected with AHS after phenobarbital treatment. In vitro experiments showed a T-lymphocyte response to the drug and an increased, dose-related, IL-6 production after drug incubation. These findings suggest that AHS may be caused by a T-lymphocyte dependent mechanism, involving pro-inflammatory cytokines. |
| Databáze: | OpenAIRE |
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