Prostate-specific membrane antigen: a new potential prognostic marker of osteosarcoma
| Autor: | Zunfu Ke, Liantang Wang, Can-Qiao Luo, Chao Zeng, Shicong Yang, Zheng Yang, Zhuo Wang |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Glutamate Carboxypeptidase II Male Cancer Research Pathology medicine.medical_specialty CD34 Bone Neoplasms Kaplan-Meier Estimate urologic and male genital diseases Young Adult Antigen Biomarkers Tumor medicine Glutamate carboxypeptidase II Humans Survival rate Osteosarcoma Neovascularization Pathologic business.industry Hematology General Medicine Osteofibrous dysplasia Prognosis medicine.disease Immunohistochemistry Staining Oncology Antigens Surface Female business |
| Zdroj: | Medical Oncology. 29:2234-2239 |
| ISSN: | 1559-131X 1357-0560 |
| DOI: | 10.1007/s12032-011-0089-4 |
| Popis: | Previous studies have demonstrated that the expression of prostate-specific membrane antigen (PSMA) is restricted to endothelium from tumor-associated neovasculature. But the expression of PSMA in osteosarcoma and its clinical significance are unknown. Using immunohistochemical analysis and quantum dot probes, we found that 46.7% (21/45) of the osteosarcoma showed positive staining for PSMA while no PSMA staining in osteofibrous dysplasia. The expression and localization of PSMA was confirmed by CD34 staining. More importantly, the expression of PSMA is correlated with tumor size, pulmonary metastasis and worse survival (survival rate 63.2% in the PSMA-negative group versus 36.6% in the PSMA-positive group). Thus, PSMA could be used as an independent prognostic marker for the osteosarcoma patients, and PSMA staining in tumor-associated neovasculature may be a potential target for antineovasculature-based therapy in osteosarcoma. |
| Databáze: | OpenAIRE |
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