Comparison of urinary human follicle-stimulating hormone and human menopausal gonadotropin for ovarian stimulation in polycystic ovarian syndrome
| Autor: | Jørgen Falck Larsen, Vibeke Schiøler, Christine Felding, Torben Larsen, Erik Bostofte |
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| Rok vydání: | 1990 |
| Předmět: |
Ovulation
endocrine system medicine.medical_specialty Menotropins medicine.drug_class Urinary system media_common.quotation_subject medicine.medical_treatment Stimulation Ovary Human follicle stimulating hormone Follicle-stimulating hormone Sex hormone-binding globulin Ovulation Induction Internal medicine medicine Humans media_common Ultrasonography Gynecology biology Estradiol business.industry Obstetrics and Gynecology General Medicine Luteinizing Hormone Polycystic ovary Endocrinology medicine.anatomical_structure Reproductive Medicine biology.protein Ovulation induction Female Gonadotropin Follicle Stimulating Hormone business Luteinizing hormone hormones hormone substitutes and hormone antagonists Polycystic Ovary Syndrome |
| Zdroj: | Fertility and sterility. 53(3) |
| ISSN: | 0015-0282 |
| Popis: | A randomized, double-blind, crossover study was carried out to compare purified urinary follicle-stimulating hormone (FSH) and human menopausal gonadotropin (hMG) for ovarian stimulation in polycystic ovarian syndrome (PCOS). Twelve patients were stimulated with FSH and hMG in three alternate cycles. FSH, luteinizing hormone (LH), estradiol, dihydroepiandrosterone sulphate, free and total testosterone, delta 5-androstenedione, sex hormone binding globulin, and ovarian volume were monitored during the stimulation. There was no difference between the dose of FSH and hMG necessary to induce preovulatory follicles in the individual patients. The mean increase of ovarian volume during stimulation with FSH and hMG was 120% and 129% respectively (no significant difference). Two patients became pregnant in the first cycle. Two other patients had delayed bleeding and positive serum-human chorionic gonadotropin. No significant difference was found in the endocrine changes during the two different stimulation methods. The LH/FSH ratio was normalized after a few days of treatment regardless of the type of stimulation. The size of the material does not permit a comparison of the efficacy of the two treatment schedules. Our clinical and ultrasonic observations do not support the theory that treatment of infertility in PCOS with FSH is more safe than with hMG. |
| Databáze: | OpenAIRE |
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