Morphology of perineuronal nets in tenascin-R and parvalbumin single and double knockout mice
| Autor: | Merdol Ibrahim, Pierre-Alain Menoud, Marco R. Celio, Udo Bartsch, Anders Haunsø, Maryse Letiembre |
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| Rok vydání: | 2000 |
| Předmět: |
endocrine system
animal structures Fluorescent Antibody Technique Tenascin Nerve Tissue Proteins Mice Neurocan medicine Animals Tenascin-R Ankyrin Lectins C-Type Molecular Biology Cell Size Cerebral Cortex Mice Knockout Neurons chemistry.chemical_classification biology Receptor-Like Protein Tyrosine Phosphatases Class 5 General Neuroscience Perineuronal net musculoskeletal system Wisteria floribunda biology.organism_classification Extracellular Matrix Cell biology Parvalbumins medicine.anatomical_structure Chondroitin Sulfate Proteoglycans chemistry Cerebral cortex embryonic structures biology.protein Neurology (clinical) Parvalbumin Developmental Biology |
| Zdroj: | Brain Research. 864:142-145 |
| ISSN: | 0006-8993 |
| DOI: | 10.1016/s0006-8993(00)02173-9 |
| Popis: | Recently identified chondroitin sulphate proteoglycans in perineuronal nets include neurocan and phosphacan. However, the function and assembly of these components has yet to be resolved. In this study we show morphological alteration in Wisteria floribunda labelled nets around cortical interneurones both in tenascin-R knockout and tenascin-R/parvalbumin double knockout mice. This alteration reflects the loss of phosphacan and neurocan from cortical nets in mice deficient in tenascin-R. No effect on the membrane related cytoskeleton, as revealed by ankyrin(R), was observed in any of the mice. These results on mice lacking tenascin-R substantiate previously reported in vitro interactions between tenascin-R and phosphacan and neurocan. |
| Databáze: | OpenAIRE |
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