Midregional pro-adrenomedullin and matrix metalloproteinase-2 levels in intrauterine growth restriction and small gestational age pregnancies: biochemical diagnostic difference
| Autor: | Andrea Tinelli, Samettin Çelik, Banuhan Şahin, Safak Hatirnaz, Canan Soyer-Calıskan |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Pro adrenomedullin Placenta Intrauterine growth restriction PLACENTAL FUNCTIONS Gestational Age 030204 cardiovascular system & hematology Matrix (biology) Matrix metalloproteinase Preeclampsia 03 medical and health sciences Adrenomedullin 0302 clinical medicine Pregnancy Internal medicine medicine Humans reproductive and urinary physiology 030219 obstetrics & reproductive medicine Fetal Growth Retardation business.industry Obstetrics and Gynecology medicine.disease female genital diseases and pregnancy complications Endocrinology Cross-Sectional Studies Small gestational age Pediatrics Perinatology and Child Health Small for gestational age Matrix Metalloproteinase 2 Female business hormones hormone substitutes and hormone antagonists |
| Zdroj: | The journal of maternal-fetalneonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians. 34(12) |
| ISSN: | 1476-4954 |
| Popis: | Midregional pro-adrenomedullin (MR-proADM) and matrix metalloproteinase-2 (MMP-2) are such proteins, that decreased levels are demonstrated in defective placental functions, as preeclampsia. The aim of the study is to compare maternal serum MR-proADM and MMP-2 levels across pregnancies with intrauterine growth restriction (IUGR), small for gestational age (SGA) and appropriate for gestational age (AGA), to biochemical screen the difference between SGA and IUGR.180 pregnant women were enrolled in a cross-sectional study: sixty pregnancies diagnosed for IUGR were included in group 1 (IUGR group), sixty pregnancies with SGA were in Group 2 (SGA group) and sixty pregnancies diagnosed for AGA, as control group. Maternal venous blood samples were collected at the time of enrollment, to assess serum MR-proADM and MMP-2 levels, by enzyme-linked immunosorbent assay (ELISA).The mean maternal serum MR-proADM and MMP-2 levels were lower in the IUGR group than in the SGA and AGA groups (Maternal serum MR-proADM and MMP-2 levels were significantly lower in pregnancies with IUGR. Maternal serum MR-proADM and MMP-2 measurements could be used to distinguish IUGR pregnancies from SGA pregnancies. |
| Databáze: | OpenAIRE |
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