Polo-like kinase 4 as a potential predictive biomarker of chemoradioresistance in locally advanced rectal cancer
| Autor: | Ilseon Hwang, Sung Uk Bae, Soon Gu Kim, Jae-Ho Lee, Sun Young Kwon, Sang Jun Byun, Hyunseung Oh, Shin Kim, Hye Won Lee |
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| Rok vydání: | 2022 |
| Předmět: |
Tumor Regression Grade
Oncology medicine.medical_specialty Histology medicine.diagnostic_test business.industry Colorectal cancer Retrospective cohort study Cell cycle medicine.disease rectal neoplasms chemoradiotherapy Pathology and Forensic Medicine polo-like kinase 4 Internal medicine Biopsy Pathology medicine biomarker RB1-214 Immunohistochemistry Biomarker (medicine) Original Article business Chemoradiotherapy |
| Zdroj: | Journal of Pathology and Translational Medicine, Vol 56, Iss 1, Pp 40-47 (2022) Journal of Pathology and Translational Medicine |
| ISSN: | 2383-7845 2383-7837 |
| DOI: | 10.4132/jptm.2021.10.07 |
| Popis: | Background: Polo-like kinase 4 (PLK4) is a serine/threonine protein kinase located in the centriole of the chromosome during the cell cycle. PLK4 overexpression has been described in a variety of many common human epithelial tumors. Conversely, PLK4 acts as a haploinsufficient tumor suppressor in some situations, highlighting the importance of strict regulation of PLK4 expression, activity, and function. Meanwhile, the importance of chemoradiation resistance in rectal cancer is being emphasized more than ever. We aimed to analyze PLK4 expression and the tumor regression grade (TRG) in patients with rectal cancer, treated with chemoradiotherapy (CRT).Methods: A retrospective study was conducted on 102 patients with rectal cancer who received preoperative CRT. Immunohistochemistry for PLK4 in paraffin-embedded tissue was performed from the biopsy and surgical specimens. Results: We found significant association between high expression of PLK4 and poor response to neoadjuvant CRT (according to both Mandard and The Korean Society of Pathologists TRG systems) in the pre-CRT specimens. Other clinicopathologic parameters did not reveal any correlation with PLK4 expression. Conclusions: This study revealed an association between high expression of PLK4 in the pre-CRT specimens and TRG. Our results indicated that PLK4 could potentially be a new predictor for CRT effect in patients with rectal cancer. |
| Databáze: | OpenAIRE |
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