A Multi-Omics Approach Reveals New Signatures in Obese Allergic Asthmatic Children
| Autor: | Bekzod Khakimov, Augusto Anguita-Ruiz, Ana Martinez-Cañavate, Mª de la Cruz Rico, Mercedes Gil-Campos, Raquel Romero, Natalia Chueca, Angel Gil, José Camacho, Concepción M. Aguilera, María D. Mesa, Mª Amelia Gomez-Llorente, Carolina Gomez-Llorente, José Morillo |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
EXHALED NITRIC-OXIDE Medicine (miscellaneous) PHENOTYPES General Biochemistry Genetics and Molecular Biology Article MECHANISMS 03 medical and health sciences 0302 clinical medicine ADOLESCENTS Medicine Metabolomics lcsh:QH301-705.5 Gastrointestinal microbiome Asthma gastrointestinal microbiome METABOLIC SYNDROME L lactate biology business.industry Leptin asthma biology.organism_classification medicine.disease Phenotype metabolomics Multi-omics approach Asthmatic children 030104 developmental biology DEFINITION lcsh:Biology (General) 030228 respiratory system multi-omics approach Immunology Cohort Mollicutes Multi omics MODERATE business |
| Zdroj: | Digibug. Repositorio Institucional de la Universidad de Granada instname Gomez-Llorente, M A, Martínez-Cañavate, A, Chueca, N, Rico, M D L C, Romero, R, Anguita-Ruiz, A, Aguilera, C M, Gil-Campos, M, Mesa, M D, Khakimov, B, Morillo, J A, Gil, Á, Camacho, J & Gomez-Llorente, C 2020, ' A Multi-Omics Approach Reveals New Signatures in Obese Allergic Asthmatic Children ', Biomedicines, vol. 8, no. 9, 359 . https://doi.org/10.3390/biomedicines8090359 Digibug: Repositorio Institucional de la Universidad de Granada Universidad de Granada (UGR) Biomedicines Volume 8 Issue 9 Biomedicines, Vol 8, Iss 359, p 359 (2020) |
| DOI: | 10.3390/biomedicines8090359 |
| Popis: | Asthma is a multifactorial condition where patients with identical clinical diagnoses do not have the same clinical history or respond to treatment. This clinical heterogeneity is reflected in the definition of two main endotypes. We aimed to explore the metabolic and microbiota signatures that characterize the clinical allergic asthma phenotype in obese children. Methods: We used a multi-omics approach combining clinical data, plasma and fecal inflammatory biomarkers, metagenomics, and metabolomics data in a cohort of allergic asthmatic children. Results: We observed that the obese allergic asthmatic phenotype was markedly associated with higher levels of leptin and lower relative proportions of plasma acetate and a member from the Clostridiales order. Moreover, allergic children with a worse asthma outcome showed higher levels of large unstained cells, fecal D lactate and D/L lactate ratio, and with a higher relative proportion of plasma creatinine and an unclassified family member from the RF39 order belonging to the Mollicutes class. Otherwise, children with persistent asthma presented lower levels of plasma citrate and dimethylsulfone. Conclusion: Our integrative approach shows the molecular heterogeneity of the allergic asthma phenotype while highlighting the use of omics technologies to examine the clinical phenotype at a more holistic level. Fundación Progreso y Salud Project PI-0373-2014 Redes temáticas de investigación cooperativa RETIC Red SAMID RD12/0026/0015 |
| Databáze: | OpenAIRE |
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