Human giant congenital melanocytic nevus exhibits potential proteomic alterations leading to melanotumorigenesis
| Autor: | In-Sung Song, Seung Hun Jeong, Je-Yoel Cho, Kwan Chul Tark, SungRyul Lee, Byoung Doo Rhee, Jin Han, Kyoung Soo Ko, Chul Gyoo Park, Min Hee Kim, Yong Kyu Kim, Nari Kim, Dae Yun Seo, Hyoung Kyu Kim |
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| Rok vydání: | 2012 |
| Předmět: |
Proteomics
Systemic analysis Protein family Giant congenital melanocytic nevi Melanotumorigenesis 14-3-3 epsilon 14-3-3 tau Biology Bioinformatics Biochemistry Biological pathway Downregulation and upregulation Western blot Congenital melanocytic nevus medicine lcsh:QH573-671 Prohibitin Molecular Biology medicine.diagnostic_test lcsh:Cytology Melanoma Research medicine.disease Cancer research |
| Zdroj: | Proteome Science PROTEOME SCIENCE(10) Proteome Science, Vol 10, Iss 1, p 50 (2012) |
| ISSN: | 1477-5956 |
| Popis: | Background A giant congenital melanocytic nevus (GCMN) is a malformation of the pigment cells. It is a distress to the patients for two reasons: one is disfigurement, and the other is the possibility of malignant changes. However, the underlying mechanisms of the development of GCMN and melanotumorigenesis in GCMN are unknown. Hence, the aim of this study was to identify the proteomic alterations and associated functional pathways in GCMN. Results Proteomic differences between GCMN (n = 3) and normal skin samples (n = 3) were analyzed by one-dimensional-liquid chromatography-tandem mass spectrometry Relative levels of the selected proteins were validated using western blot analysis. The biological processes associated with the abundance modified proteins were analyzed using bioinformatic tools. Among the 46 abundance modified proteins, expression of 4 proteins was significantly downregulated and expression of 42 proteins was significantly upregulated in GCMN compared to normal skin samples (p Conclusion These findings suggest that GCMN exhibits potential proteomic alterations, which may play a role in melanotumorigenesis, and the significant alteration of 14-3-3 family proteins could be a key regulator of the biological pathway remodeling in GCMN. |
| Databáze: | OpenAIRE |
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