Diabetes and Breast Cancer Subtypes
| Autor: | Bronsveld, Heleen K., Jensen, Vibeke Frøkjær, Vahl, Pernille, De Bruin, Marie L., Cornelissen, Sten, Sanders, Joyce, Auvinen, Anssi, Haukka, Jari, Andersen, Morten, Vestergaard, Peter, Schmidt, Marjanka K, Afd Pharmacoepi & Clinical Pharmacology, Pharmacoepidemiology and Clinical Pharmacology |
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| Přispěvatelé: | Clinicum, Jari Haukka / Principal Investigator, Department of Public Health, Yhteiskuntatieteiden tiedekunta - Faculty of Social Sciences, University of Tampere, Afd Pharmacoepi & Clinical Pharmacology, Pharmacoepidemiology and Clinical Pharmacology |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Oncology
Cross-sectional study Physiology medicine.medical_treatment POPULATION-BASED COHORT Cancer Treatment lcsh:Medicine Biochemistry Body Mass Index MELLITUS 0302 clinical medicine Endocrinology Breast Tumors ComputingMilieux_COMPUTERSANDEDUCATION Medicine and Health Sciences 030212 general & internal medicine lcsh:Science GENE-EXPRESSION Medicine(all) Aged 80 and over RISK OUTCOMES Multidisciplinary Agricultural and Biological Sciences(all) Sisätaudit - Internal medicine Age Factors ASSOCIATION Middle Aged INSULIN 3. Good health Postmenopause Physiological Parameters 030220 oncology & carcinogenesis Female Research Article Adult medicine.medical_specialty medicine.drug_class Biolääketieteet - Biomedicine Endocrine Disorders Breast Neoplasms 03 medical and health sciences Breast cancer Diagnostic Medicine Diabetes mellitus Internal medicine Syöpätaudit - Cancers Progesterone receptor Breast Cancer medicine Diabetes Mellitus Cancer Detection and Diagnosis Humans METAANALYSIS Aged Gynecology Diabetic Endocrinology business.industry Biochemistry Genetics and Molecular Biology(all) Insulin MORTALITY lcsh:R Body Weight Cancers and Neoplasms Biology and Life Sciences medicine.disease Hormones BODY-MASS INDEX Cross-Sectional Studies Premenopause Estrogen Metabolic Disorders Etiology Diabetes Diagnosis and Management lcsh:Q 3111 Biomedicine business Body mass index Genetics and Molecular Biology(all) |
| Zdroj: | PLoS ONE Bronsveld, H K, Jensen, V, Vahl, P, De Bruin, M L, Cornelissen, S, Sanders, J, Auvinen, A, Haukka, J, Andersen, M, Vestergaard, P & Schmidt, M K 2017, ' Diabetes and Breast Cancer Subtypes ', PLOS ONE, vol. 12, no. 1, e0170084 . https://doi.org/10.1371/journal.pone.0170084 Bronsveld, H K, Jensen, V, Vahl, P, De Bruin, M L, Cornelissen, S, Sanders, J, Auvinen, A, Haukka, J, Andersee, M, Vestergaard, P & Schmidt, M K 2017, ' Diabetes and Breast Cancer Subtypes ', P L o S One, vol. 12, no. 1, 0170084 . https://doi.org/10.1371/journal.pone.0170084 PLoS One, 12(1). Public Library of Science PLoS ONE, Vol 12, Iss 1, p e0170084 (2017) |
| ISSN: | 1932-6203 |
| Popis: | BackgroundWomen with diabetes have a worse survival after breast cancer diagnosis compared to women without diabetes. This may be due to a different etiological profile, leading to the development of more aggressive breast cancer subtypes. Our aim was to investigate whether insulin and non-insulin treated women with diabetes develop specific clinicopathological breast cancer subtypes compared to women without diabetes.Methods and FindingsThis cross-sectional study included randomly selected patients with invasive breast cancer diagnosed in 2000-2010. Stratified by age at breast cancer diagnosis (50 years), women with diabetes were 2:1 frequency-matched on year of birth and age at breast cancer diagnosis (both in 10-year categories) to women without diabetes, to select similar to 300 patients with tumor tissue available. Tumor MicroArrays were stained by immunohistochemistry for estrogen and progesterone receptor (ER, PR), HER2, Ki67, CK5/6, CK14, and p63. A pathologist scored all stains and revised morphology and grade. Associations between diabetes/insulin treatment and clinicopathological subtypes were analyzed using multivariable logistic regression. Morphology and grade were not significantly different between women with diabetes (n = 211) and women without diabetes (n = 101), irrespective of menopausal status. Premenopausal women with diabetes tended to have more often PR-negative (OR = 2.44(95%C1:1.07-5.55)), HER2-negative (OR = 2.84(95%C1:1.11-7.22)), and basal-like (OR = 3.14(95%C1:1.03-9.60) tumors than the women without diabetes, with non-significantly increased frequencies of ER-negative (OR = 2.48(95`)/X1:0.95-6.45)) and triple negative (OR = 2.60(95%CI:0.88-7.67) tumors. After adjustment for age and BMI, the associations remained similar in size but less significant. We observed no evidence for associations of clinicopathological subtypes with diabetes in postmenopausal women, or with insulin treatment in general.ConclusionsWe found no compelling evidence that women with diabetes, treated with or without insulin, develop different breast cancer subtypes than women without diabetes. However, premenopausal women with diabetes tended to develop breast tumors that do not express hormonal receptors, which are typically associated with poor prognosis. |
| Databáze: | OpenAIRE |
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