| Autor: |
Samuel R, Miller, Shaphan R, Jernigan, Robert J, Abraham, Gregory D, Buckner |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
Journal of Vascular and Interventional Radiology. 34:11-20 |
| ISSN: |
1051-0443 |
| DOI: |
10.1016/j.jvir.2022.07.032 |
| Popis: |
To utilize an in vitro microvascular hepatic tumor model to compare the deposition characteristics of glass yttrium-90 microspheres using the dual-syringe (DS) and traditional bolus administration methods.The microvascular tumor model represented a 3.5-cm tumor in a 1,400-cmOverall, the degree of on-target deposition of the microspheres was 85% ± 11%, with no significant differences between the administration methods. Although the distal penetration into the tumor arterioles was approximately 15 mm (from the second microvascular bifurcation of the tumor model) for all the cases, the distal peak particle counts were significantly higher for the DS delivery case (approximately 5 × 10The use of this new in vitro microvascular hepatic tumor model demonstrated that the administration method can affect the deposition of yttrium-90 microspheres within a tumor, with greater distal deposition and more uniform tumor coverage when the microspheres are delivered at consistent concentrations using a DS delivery device. The BD administration method was associated with less favorable deposition characteristics of the microspheres. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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