Age‐specific incidence rates and risk factors for respiratory syncytial virus‐associated lower respiratory tract illness in cohort children under 5 years old in the Philippines

Autor: Socorro Lupisan, Hitoshi Oshitani, Mariko Saito-Obata, Akira Suzuki, Mayuko Saito, Fumihiko Ueno, Michiko Okamoto, Hananiah D Aloyon, Veronica Tallo, Raita Tamaki, Taro Kamigaki, Edelwisa Segubre-Mercado
Rok vydání: 2019
Předmět:
Male
Pulmonary and Respiratory Medicine
medicine.medical_specialty
Pediatrics
Epidemiology
respiratory syncytial virus
Philippines
viruses
lower respiratory tract illness
Respiratory Syncytial Virus Infections
030312 virology
Virus
03 medical and health sciences
Risk Factors
Nasopharynx
cohort study
Respiratory Syncytial Virus Vaccines
medicine
Humans
Prospective Studies
Respiratory system
Prospective cohort study
Lung
Respiratory Tract Infections
0303 health sciences
business.industry
Incidence
Age Factors
Public Health
Environmental and Occupational Health
Infant
virus diseases
Original Articles
respiratory system
pulse oximetry
respiratory tract diseases
Hospitalization
Vaccination
Infectious Diseases
medicine.anatomical_structure
Child
Preschool
Respiratory Syncytial Virus
Human
Cohort
Original Article
Female
business
Respiratory tract
Cohort study
Zdroj: Influenza and Other Respiratory Viruses
ISSN: 1750-2659
1750-2640
Popis: Background Respiratory syncytial virus (RSV) is one of the main viral causes of lower respiratory tract illness (LRTI), especially in young children. RSV vaccines, including maternal and infant vaccines, are under development; however, more epidemiological studies are needed to develop effective vaccination strategies. Objectives To estimate detailed age-specific incidence rates and severity of RSV-associated LRTI (RSV-LRTI) using data from a community-based prospective cohort study in the Philippines. Patients/methods Cohort children who visited health facilities due to acute respiratory symptoms were identified, and nasopharyngeal swabs were collected to detect RSV. The severity of RSV-LRTI was assessed using the severity definition proposed by the World Health Organization. Risk factors for developing RSV-LRTI and contribution of SpO2 measurement were also evaluated. Results A total of 395 RSV episodes which occurred in children aged 2-59 months were categorised as 183 RSV-LRTI, 72 as severe RSV-LRTI and 29 as very severe RSV-LRTI. Children aged 3-5 months had the highest incidence rate of RSV-LRTI, at 207.4 per 1000 child-years (95% CI: 149.0-279.5). Younger age group, place of living and low educational level of caregivers were associated with developing RSV-LRTI. Clinical manifestations had low levels of agreement with hypoxaemia as measured by pulse oximeter. Conclusion The highest burden of RSV was observed in young infants aged 3-5 months, whereas the burden was also high in those aged 12-20 months. Future vaccination strategies should consider the protection of older children, especially those aged one year, as well as young infants.
Databáze: OpenAIRE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje