Amplification Patterns of Three Genomic Regions Predict Distant Recurrence in Breast Carcinoma
| Autor: | Peter T. Hraber, Patti Doherty, Katie Doeden, Lisa Davis, Bryan Hall, Cole Harris, John Hozier, Yumiko Sakai, Thèrése Bocklage, John Alsobrook, Lei Tang, Thomas M. Williams, Ian Rabinowitz |
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| Rok vydání: | 2007 |
| Předmět: |
Oncology
medicine.medical_specialty medicine.drug_class Gene Dosage Breast Neoplasms Biology Gene dosage Disease-Free Survival Pathology and Forensic Medicine Breast cancer Recurrence Internal medicine Gene duplication Biomarkers Tumor medicine Humans In Situ Hybridization Fluorescence medicine.diagnostic_test Genome Human Carcinoma Ductal Breast Gene Amplification Odds ratio Middle Aged Prognosis medicine.disease Confidence interval Receptors Estrogen Estrogen Lymphatic Metastasis Immunology Molecular Medicine Female Receptors Progesterone Breast carcinoma Regular Articles Follow-Up Studies Fluorescence in situ hybridization |
| Zdroj: | The Journal of Molecular Diagnostics. 9:327-336 |
| ISSN: | 1525-1578 |
| DOI: | 10.2353/jmoldx.2007.060079 |
| Popis: | Currently used clinical and histopathological parameters imprecisely define the risk of distant recurrence in breast cancer, underscoring the need for more informative prognostic markers. In the present fluorescence in situ hybridization study of archived surgical specimens, we derived an algorithm for computing a prognostic index (PI) from DNA copy numbers of three genomic regions (CYP24, PDCD6IP, and BIRC5) for estrogen/progesterone receptor-positive (ER/PR+) cancers and a distinct PI (based on NR1D1, SMARCE1, and BIRC5) for estrogen/progesterone receptor-negative (ER/PR−) cancers. Among independent test cases stratified by PI, recurrence rates were significantly higher among high-risk patients than low-risk patients for both ER/PR+ (odds ratio = 9.52, 95% confidence interval >2.12, P = 0.0024) and ER/PR− (odds ratio = 12.3, 95% confidence interval >1.45, P = 0.0188) cancers. Among the entire population, recurrences were significantly more prevalent for cases with PI above the medians for both ER/PR+ (Fisher’s exact, P = 1.19 × 10−5) and ER/PR− (P = 0.0025) patients and for the node-negative subsets (ER/PR+ node-negative, P = 0.042 and ER/PR− node-negative, P = 0.039). In conclusion, these markers perform well in comparison with other criteria for recurrence risk assessment and can be used with routinely formalin-fixed, paraffin-embedded surgical specimens. |
| Databáze: | OpenAIRE |
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