Synthesis and anti-inflammatory activity of novel pyridazine and pyridazinone derivatives as non-ulcerogenic agents
| Autor: | Nadia A. Khalil, Eman M. Ahmed, Kholoud I. Eissa, Makarem M. Saeed |
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| Rok vydání: | 2011 |
| Předmět: |
Drug
Male medicine.drug_class Cell Survival media_common.quotation_subject Pharmacology Anti-inflammatory Cell Line Pyridazine Rats Sprague-Dawley chemistry.chemical_compound Mice In vivo Drug Discovery medicine Animals MTT assay Stomach Ulcer media_common Cyclooxygenase 2 Inhibitors Dose-Response Relationship Drug Chemistry Organic Chemistry Anti-Inflammatory Agents Non-Steroidal In vitro Rats Pyridazines Cell culture Rapid onset Molecular Medicine |
| Zdroj: | Archives of pharmacal research. 35(12) |
| ISSN: | 1976-3786 |
| Popis: | Herein, we report the synthesis and pharmacological properties of several series of pyridazine and pyridazinone derivatives. All the synthesized compounds were tested, in vivo, for their anti-inflammatory and ulcerogenic properties against indomethacin, as a reference compound. Compounds 4a and 9d have shown a potent anti-inflammatory activity more than indomethacin with rapid onset of action and safe gastric profile. The latter compounds were then selected for further investigation. In the MTT assay in vitro, both compounds were identified as potent and selective COX-2 inhibitors. |
| Databáze: | OpenAIRE |
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