HIV reservoir size is determined prior to ART initiation and linked to CD8 T cell activation and memory expansion
| Autor: | Nneka Nwokolo, John Thornhill, Helen Brown, M Pace, Eva Zilber, Genevieve E. Martin, Jacob Hurst, J Meyerowitz, Freya M Shearer, Natalia Olejniczak, Nicola Robinson, E Hopkins, Sarah Fidler, J Fox, John Frater, Julianne Lwanga, Christian B. Willberg |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0303 health sciences
Effector Art initiation Human immunodeficiency virus (HIV) Biology medicine.disease_cause Antiretroviral therapy Primary HIV infection 3. Good health 03 medical and health sciences Cd38 expression 0302 clinical medicine Immunology medicine Cytotoxic T cell 030212 general & internal medicine CD8 030304 developmental biology |
| DOI: | 10.1101/580308 |
| Popis: | Initiation of antiretroviral therapy (ART) in early compared with chronic HIV infection is associated with a smaller HIV reservoir. This longitudinal analysis of 63 individuals who commenced ART during primary HIV infection (PHI) investigates which pre-and post-therapy factors associate most closely with reservoir size (HIV DNA) following treatment initiation during PHI. The best predictor of reservoir size at one-year was pre-ART HIV DNA which was in turn significantly associated with CD8 memory differentiation (effector memory, naïve and T-betnegEomesnegsubsets), CD8 T cell activation (CD38 expression) and PD-1 and Tim-3 expression on memory CD4 T cells. No associations were found for any immunological variables following one-year of ART. HIV reservoir size is determined around the time of ART initiation in individuals treated during PHI. CD8 T cell activation and memory expansion are linked to HIV reservoir size, suggesting the importance of the initial host-viral interplay in eventual reservoir size. |
| Databáze: | OpenAIRE |
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