Is Hypospadias Associated with Prenatal Exposure to Endocrine Disruptors? A French Collaborative Controlled Study of a Cohort of 300 Consecutive Children Without Genetic Defect

Autor: Jean-Stéphane Valla, Nadege Fauconnet-Servant, Jean-Pierre Daurès, Eric Dobremez, Amel Zahhaf, Sylvie Broussous, Pascal Philibert, Jean Breaud, Mattea Orsini, Jean-Yves Kurzenne, Nicolas Kalfa, Françoise Paris, Florence Bastiani, Rachel Reynaud, Jean-Michel Guys, Laura Gaspari, Pierre Alessandrini, Thierry Merrot, Myriam Haddad, Kathy Wagner, Helene Lehors, Françoise Audran, Gérard Morisson Lacombe, Charles Sultan
Přispěvatelé: Département Chirurgie Pédiatrique [CHRU Montpellier], Pôle Femme Mère Enfant [CHRU Montpellier], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Université de Montpellier (UM), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Institut de génétique humaine (IGH), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherche en Cancérologie de Montpellier (IRCM - U1194 Inserm - UM), CRLCC Val d'Aurelle - Paul Lamarque-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Aide à la Décision pour une Médecine Personnalisé - Laboratoire de Biostatistique, Epidémiologie et Recherche Clinique - EA 2415 (AIDMP), Université Montpellier 1 (UM1)-Université de Montpellier (UM), Hôpital de la Timone [CHU - APHM] (TIMONE), Service de pédiatrie multidisciplinaire [Hôpital de la Timone Enfants - APHM], Hôpital Nord [CHU - APHM], Centre Hospitalier Universitaire de Nice (CHU Nice), Hôpital Saint-Joseph [Marseille], Service de chirurgie infantile, CHU Bordeaux [Bordeaux]-Groupe hospitalier Pellegrin
Rok vydání: 2015
Předmět:
Zdroj: European Urology
European Urology, Elsevier, 2015, 68 (6), pp.1023-1030. ⟨10.1016/j.eururo.2015.05.008⟩
ISSN: 1873-7560
0302-2838
1421-993X
DOI: 10.1016/j.eururo.2015.05.008⟩
Popis: International audience; BACKGROUND:Numerous studies have focused on the association between endocrine-disrupting chemicals (EDCs) and hypospadias. Phenotype variability, the absence of representative comparison groups and concomitant genetic testing prevent any definitive conclusions.OBJECTIVE:To identify the role of occupational and environmental exposures to EDCs in nongenetic isolated hypospadias.DESIGN, SETTING, AND PARTICIPANTS:A total of 408 consecutive children with isolated hypospadias and 302 normal boys were prospectively included (2009-2014) in a multi-institutional study in the south of France, the area of the country with the highest prevalence of hypospadias surgery.OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS:In patients without AR, SRD5A2, and MAMLD1 mutations, parental occupational and professional exposures to EDCs were evaluated based on European questionnaire QLK4-1999-01422 and a validated job-exposure matrix for EDCs. Environmental exposure was estimated using the zip code, the type of surrounding hazards, and distance from these hazards. Multivariate analysis was performed.RESULTS:Fetal exposure to EDCs around the window of genital differentiation was more frequent in the case of hypospadias (40.00% vs 17.55%, odds ratio 3.13, 95% confidence interval 2.11-4.65). The substances were paints/solvents/adhesives (16.0%), detergents (11.0%), pesticides (9.0%), cosmetics (5.6%), and industrial chemicals (4.0%). Jobs with exposure were more frequent in mothers of hypospadiac boys (19.73% vs 10.26%, p=0.0019), especially cleaners, hairdressers, beauticians, and laboratory workers. Paternal job exposure was more frequent in the cases of hypospadias (40.13% vs 27.48%, p=0.02). Industrial areas, incinerators, and waste areas were more frequent within a 3-km radius for mothers of hypospadiac boys (13.29% vs. 6.64%, p
Databáze: OpenAIRE
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