Critical Care Workers Have Lower Seroprevalence of SARS-CoV-2 IgG Compared with Non-patient Facing Staff in First Wave of COVID19
| Autor: | George Carnell, James A. Nathan, Jessica Gronlund, Mina Paloniemi, Jakub Luptak, Paul Tonks, Sumita Pai, Soraya Ebrahimi, David A. Wells, Sara Lear, Leo C. James, Lourdes Ceron-Gutierrez, Rainer Döffinger, Helen Baxendale, Jonathan L. Heeney, John A. G. Briggs, Ashleigh Sayer, Angalee Nadesalingham, Guinevere L. Grice, Xiaoli Ziong |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
seroprevalence business.industry RC86-88.9 SARS-CoV-2 Convalescence media_common.quotation_subject COVID-19 Medical emergencies. Critical care. Intensive care. First aid General Medicine medicine.disease health care workers critical care Intensive care Pandemic Health care Cohort Emergency medicine Hospital-acquired infection medicine Seroprevalence Seroconversion business media_common Research Article |
| Zdroj: | The Journal of Critical Care Medicine The Journal of Critical Care Medicine, Vol 7, Iss 3, Pp 199-210 (2021) |
| ISSN: | 2393-1817 2393-1809 |
| Popis: | Introduction In early 2020, at first surge of the coronavirus disease 2019 (COVID-19) pandemic, many health care workers (HCW) were re-deployed to critical care environments to support intensive care teams looking after patients with severe COVID-19. There was considerable anxiety of increased risk of COVID-19 for these staff. To determine whether critical care HCW were at increased risk of hospital acquired infection, we explored the relationship between workplace, patient facing role and evidence of immune exposure to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) within a quaternary hospital providing a regional critical care response. Routine viral surveillance was not available at this time. Methods We screened over 500 HCW (25% of the total workforce) for history of clinical symptoms of possible COVID19, assigning a symptom severity score, and quantified SARS-CoV-2 serum antibodies as evidence of immune exposure to the virus. Results Whilst 45% of the cohort reported symptoms that they consider may have represented COVID-19, 14% had evidence of immune exposure. Staffs in patient facing critical care roles were least likely to be seropositive (9%) and staff working in non-patient facing roles most likely to be seropositive (22%). Anosmia and fever were the most discriminating symptoms for seropositive status. Older males presented with more severe symptoms. Of the 12 staff screened positive by nasal swab (10 symptomatic), 3 showed no evidence of seroconversion in convalescence. Conclusions Patient facing staff working in critical care do not appear to be at increased risk of hospital acquired infection however the risk of nosocomial infection from non-patient facing staff may be more significant than previous recognised. Most symptoms ascribed to possible COVID-19 were found to have no evidence of immune exposure however seroprevalence may underrepresent infection frequency. Older male staff were at the greatest risk of more severe symptoms. |
| Databáze: | OpenAIRE |
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