Role of Dietary Nutritional Treatment on Hepatic and Intestinal Damage in Transplantation with Steatotic and Non-Steatotic Liver Grafts from Brain Dead Donors
| Autor: | Araní Casillas-Ramírez, Carmen A. Peralta, Carlos Rojano-Alfonso, Marc Micó-Carnero, Alfredo Sanchez-Gonzalez, Albert Caballeria-Casals |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
0301 basic medicine medicine.medical_treatment polysaccharides Vascular permeability Gut flora Liver transplantation ischemia-reperfusion chemistry.chemical_compound Adenosine Triphosphate 0302 clinical medicine intestinal inflammation TX341-641 glucose Phospholipids Nutrition and Dietetics biology Glycogen liver transplantation Tissue Donors Intestines Liver Intercellular Signaling Peptides and Proteins Emulsions 030211 gastroenterology & hepatology medicine.symptom lipid emulsion steatotic liver grafts medicine.medical_specialty Inflammation Article 03 medical and health sciences Internal medicine medicine Animals brain death Obesity gut microbiota Nutrition. Foods and food supply business.industry Growth factor biology.organism_classification Liver Glycogen Rats Rats Zucker Soybean Oil Fatty Liver Transplantation Disease Models Animal 030104 developmental biology Endocrinology chemistry TLR4 business Food Science |
| Zdroj: | Nutrients Volume 13 Issue 8 Nutrients, Vol 13, Iss 2554, p 2554 (2021) |
| ISSN: | 2072-6643 |
| DOI: | 10.3390/nu13082554 |
| Popis: | Herein, we investigate whether: (1) the administration of glucose or a lipid emulsion is useful in liver transplantation (LT) using steatotic (induced genetically or nutritionally) or non-steatotic livers from donors after brain death (DBDs) and (2) any such benefits are due to reductions in intestinal damage and consequently to gut microbiota preservation. In recipients from DBDs, we show increased hepatic damage and failure in the maintenance of ATP, glycogen, phospholipid and growth factor (HGF, IGF1 and VEGFA) levels, compared to recipients from non-DBDs. In recipients of non-steatotic grafts from DBDs, the administration of glucose or lipids did not protect against hepatic damage. This was associated with unchanged ATP, glycogen, phospholipid and growth factor levels. However, the administration of lipids in steatotic grafts from DBDs protected against damage and ATP and glycogen drop and increased phospholipid levels. This was associated with increases in growth factors. In all recipients from DBDs, intestinal inflammation and damage (evaluated by LPS, vascular permeability, mucosal damage, TLR4, TNF, IL1, IL-10, MPO, MDA and edema formation) was not shown. In such cases, potential changes in gut microbiota would not be relevant since neither inflammation nor damage was evidenced in the intestine following LT in any of the groups evaluated. In conclusion, lipid treatment is the preferable nutritional support to protect against hepatic damage in steatotic LT from DBDs the benefits were independent of alterations in the recipient intestine. |
| Databáze: | OpenAIRE |
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