Synthesis and positive inotropic activity of novel pyrimido-[5,4-b][1,4]oxazin-7(8H)-ones

Autor:	Péter Mátyus, E. Diesler, Kosary Judit, A. Tegdes, S Gyürki, Makk Nandor, György Rabloczky, M. Kurthy, L Jaszlits, K. Czako, G Cseh, Endre Kasztreiner
Předmět:	Pharmacology Inotrope Bicyclic molecule Chemistry Stereochemistry Organic Chemistry Drug Discovery medicine Biological activity General Medicine Amrinone medicine.drug
Zdroj:	Scopus-Elsevier
Popis:	Seventy-five compounds I were synthesized and tested for positive inotropic activity. Some derivatives (22, 24, 54) showed an activity comparable to that of amrinone. Compound 24 was selected for preclinical study. According to the biochemical and pharmacological data its activity may involve a novel mechanism(s).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2ce578121a0714d5afbb4e6d25b01ae http://www.scopus.com/inward/record.url?eid=2-s2.0-0025338322&partnerID=MN8TOARS Zobrazit plný text záznamu