Grafting cyclodextrins to calcium phosphate ceramics for biomedical applications

Autor:	Naseem Theilgaard, Kim Lambertsen Larsen, Maria V. Juhl, Jeppe Lund Nielsen, Peter Andreas Lund Jacobsen
Rok vydání:	2011
Předmět:	chemistry.chemical_classification Thermogravimetric analysis Cyclodextrin General Chemistry Condensed Matter Physics Grafting Phosphate Silane Fluorescence spectroscopy chemistry.chemical_compound chemistry Covalent bond Monolayer Organic chemistry Food Science Nuclear chemistry
Zdroj:	Jacobsen, P A L, Nielsen, J L, Juhl, M V, Theilgaard, N & Larsen, K L 2012, ' Grafting cyclodextrins to calcium phosphate ceramics for biomedical applications ', Journal of Inclusion Phenomena and Macrocyclic Chemistry, vol. 72, no. 1-2, pp. 173-181 . https://doi.org/10.1007/s10847-011-9958-x
ISSN:	1573-1111 0923-0750
DOI:	10.1007/s10847-011-9958-x
Popis:	The grafting of hydroxyapatite/beta-tricalcium phosphate with β-cyclodextrin was achieved using a two step reaction with (3-glycidyloxypropyl)trimethoxysilane as a linker. Firstly, the silane group was brought to react with the hydroxyl groups at the surface of the hydroxyapatite/beta-tricalcium phosphate and secondly, the epoxy group was brought to react with the β-cyclodextrin. The amount and distribution of covalently bound β-cyclodextrin were investigated by thermogravimetric analysis, colorimetric total sugar assay, fluorescence spectroscopy and confocal laser scanning microscopy. The concentration of grafted β-cyclodextrin was found to be approximately 3.5 μmol per gram of material corresponding to an almost complete surface coverage, when assuming a closed hexagonal packed monolayer.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2cc81a677121557700ae5a0806ff289 https://doi.org/10.1007/s10847-011-9958-x Zobrazit plný text záznamu Full text from SpringerLink