Effect of benzo( )pyrene treatment on the benzo( )pyrene hydroxylase activity in maternal liver, placenta, and fetus of the rat during day 13 to day 18 of gestation
| Autor: | H. J. Merker, Eva Schlede |
|---|---|
| Rok vydání: | 1972 |
| Předmět: |
Oral dose
medicine.medical_specialty Placenta Gestational Age Body weight Endoplasmic Reticulum Mixed Function Oxygenases chemistry.chemical_compound Fetus Pregnancy Internal medicine medicine Animals Benzopyrenes Maternal-Fetal Exchange Pharmacology chemistry.chemical_classification biology business.industry General Medicine Enzyme assay Rats Trophoblasts Microscopy Electron Enzyme Endocrinology medicine.anatomical_structure chemistry Liver Enzyme Induction biology.protein Gestation Pyrene Female business |
| Zdroj: | Naunyn-Schmiedeberg's archives of pharmacology. 272(1) |
| ISSN: | 0028-1298 |
| Popis: | Pregnant rats were treated with an oral dose of 40.0 mg benzo(α) pyrene (BP) per kg body weight and were sacrificed 24 h later. Maternal liver, placenta, and fetus were assayed for BP-hydroxylase activity. The enzyme activity was measured from day 13 to day 18 of gestation. Pretreatment of rats with BP results in an approximately 15-fold increase of BP-hydroxylase activity in the maternal liver compared to the enzyme activity in the liver of control animals. These enzyme levels were maintained throughout the duration of gestation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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