Two VH5 family genes expressed by human peripheral B cells display differential mutational frequencies in the VH region
| Autor: | Masayuki Murata, Kouzaburo Yamaji, Seizaburo Kashiwagi, Jun Hayashi, Hideyuki Ikematsu, Yong Chong, Shigeki Nabeshima |
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| Rok vydání: | 2002 |
| Předmět: |
Adult
Male Molecular Sequence Data Immunology Immunoglobulin Variable Region Complementarity determining region Biology medicine.disease_cause D-segment medicine Humans Amino Acid Sequence Codon Molecular Biology Gene Peptide sequence B cell Aged Aged 80 and over Genetics B-Lymphocytes Mutation Base Sequence V(D)J recombination Middle Aged Complementarity Determining Regions Molecular biology medicine.anatomical_structure Immunoglobulin heavy chain Female Immunoglobulin Heavy Chains |
| Zdroj: | Molecular Immunology. 39:31-38 |
| ISSN: | 0161-5890 |
| DOI: | 10.1016/s0161-5890(02)00054-8 |
| Popis: | The heavy chain variable segment gene (V(H))5 family, one of the seven immunoglobulin (Ig) V(H) families, contains two functional genes, VH251 and VH32. To investigate functional differences between these V(H)5 family genes, V(H) segments expressed by human peripheral B cells were sequenced and analyzed. One hundred fifty-three sequences with unique V(H)DJ(H) recombinations were obtained from 17 adults. The mutational frequency of VH32 derived sequences (6.4%) was higher than that of VH251 derived sequences (4.4%), resulting in a significant difference (P |
| Databáze: | OpenAIRE |
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